Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353000
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGuilherme Damasio, Viviane Aparecida-
dc.contributor.authorunicampPaula, Eneida de-
dc.typeArtigopt_BR
dc.titlePoloxamer-based binary hydrogels for delivering tramadol hydrochloride: sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluationpt_BR
dc.contributor.authorMendonca dos Santos, Ana Claudia-
dc.contributor.authorSantos Akkari, Alessandra Cristina-
dc.contributor.authorSilva Ferreira, Iasmin Rosanne-
dc.contributor.authorMaruyama, Cintia Rodrigues-
dc.contributor.authorPascoli, Monica-
dc.contributor.authorGuilherme, Viviane Aparecida-
dc.contributor.authorde Paula, Eneida-
dc.contributor.authorFraceto, Leonardo Fernandes-
dc.contributor.authorde Lima, Renata-
dc.contributor.authorMelo, Patricia da Silva-
dc.contributor.authorde Araujo, Daniele Ribeiro-
dc.subjectLidocaínapt_BR
dc.subjectCopolímerospt_BR
dc.subject.otherlanguageLidocainept_BR
dc.subject.otherlanguageCopolymerspt_BR
dc.description.abstractIn this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release profiles. In particular, we evaluated the cytotoxicity, genotoxicity, and in vivo pharmacological performance of PL 407 and PL 407-PL 188 hydrogels containing tramadol (TR) to analyze its potential treatment of acute pain. Drug-micelle interaction studies showed the formation of PL 407-PL 188 binary systems and the drug partitioning into the micelles. Characterization of the sol-gel transition phase showed an increase on enthalpy variation values that were induced by the presence of TR hydrochloride within the PL 407 or PL 407-PL 188 systems. Hydrogel dissolution occurred rapidly, with approximately 30%-45% of the gel dissolved, reaching similar to 80%-90% up to 24 hours. For in vitro release assays, formulations followed the diffusion Higuchi model and lower K-rel values were observed for PL 407 (20%, K-rel = 112.9 +/- 10.6 mu g . h(-1/2)) and its binary systems PL 407-PL 188 (25%-5% and 25%-10%, K-rel = 80.8 +/- 6.1 and 103.4 +/- 8.3 mu g.h(-1/2), respectively) in relation to TR solution (K-rel = 417.9 +/- 47.5 mu g.h(-1/2), P<0.001). In addition, the reduced cytotoxicity (V79 fibroblasts and hepatocytes) and genotoxicity (V79 fibroblasts), as well as the prolonged analgesic effects (>72 hours) pointed to PL-based hydrogels as a potential treatment, by subcutaneous injection, for acute painpt_BR
dc.relation.ispartofInternational journal of nanomedicinept_BR
dc.publisher.cityMacclesfieldpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherDove Medicalpt_BR
dc.date.issued2015-
dc.language.isoengpt_BR
dc.description.volume10pt_BR
dc.description.firstpage2391pt_BR
dc.description.lastpage2401pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn1178-2013pt_BR
dc.identifier.doi10.2147/IJN.S72337pt_BR
dc.identifier.urlhttps://www.epj-conferences.org/articles/epjconf/abs/2015/14/epjconf_icnfp2014_04016/epjconf_icnfp2014_04016.htmlpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber487619/2012-9; 300952/2010-4; 309612/2013-6pt_BR
dc.description.sponsordocumentnumber2006/00121-9; 2010/11475-1; 2010/13088-5pt_BR
dc.date.available2020-12-04T19:31:21Z-
dc.date.accessioned2020-12-04T19:31:21Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-12-04T19:31:21Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-19T19:00:12Z : No. of bitstreams: 1 000351616800001.pdf: 743701 bytes, checksum: 2eedcd506acfe04e6cc6fd8b8e7f7877 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-04T19:31:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353000-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordDrugpt_BR
dc.subject.keywordAqueous-solutionpt_BR
dc.identifier.source000351616800001pt_BR
dc.creator.orcid0000-0002-1008-2906pt_BR
dc.creator.orcid0000-0003-4504-5723pt_BR
dc.type.formArtigopt_BR
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