Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/352863
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBlock, Daniel Bueno-
dc.contributor.authorunicampBoer, Patricia Aline-
dc.contributor.authorunicampGontijo, Jose Antonio Rocha-
dc.typeArtigopt_BR
dc.titleFetal kidney programming by maternal smoking exposure: effects on kidney structure, blood pressure and urinary sodium excretion in adult offspringpt_BR
dc.contributor.authorBlock, Daniel B.-
dc.contributor.authorMesquita, Flavia F.-
dc.contributor.authorde Lima, Ize P.-
dc.contributor.authorBoer, Patricia A.-
dc.contributor.authorGontijo, Jose A. R.-
dc.subjectHábito de fumarpt_BR
dc.subjectHipertensãopt_BR
dc.subjectGravidezpt_BR
dc.subject.otherlanguageSmokingpt_BR
dc.subject.otherlanguageHypertensionpt_BR
dc.subject.otherlanguagePregnancypt_BR
dc.description.abstractFetal programming by different insults results in low birth weight and reduction in nephron number increasing the risk for adult development of cardiovascular and renal diseases. Maternal smoking is an important modifiable adverse fetal exposure worldwide and leads to a decrease in the offspring's birth weight. Thus far, the specific adverse fetal smoking exposures and mechanisms underlying these associations on renal development and functional disorder are unclear. The present study investigates, in adult male rats, the effect of smoking exposure (Sk) in uteri on blood pressure (BP) by an indirect tail-cuff method using an electrosphygmomanometer, and its association with nephron structure by stereological estimation, immunohistochemical and histological techniques, in parallel with kidney function creatinine and lithium clearance. The current study showed in a 16-week old Sk offspring enhanced arterial blood pressure associated with, reduced urinary sodium excretion and higher TGF-beta 1 glomerular expression. Sk glomeruli also presented an upregulated collagen and fibronectin deposition intrinsically related to fibrotic process as compared to age-matched control group. Here, we demonstrate that fetal-programmed Sk offspring present pronounced glomerular TGF-beta 1 and fibrotic marker expression that may, subsequently, promote a glomerular epithelial-mesenchymal transition activated process in an Sk offspring. Although the precise mechanism responsible for the subsequently renal morphological and functional response in Sk offspring is incompletely known, the current data suggest that changes in renal function are conducive to excess sodium tubule reabsorption that is associated with enhanced TGF-beta 1, fibronectin and collagen deposition, intrinsically related to fibrotic process, might potentiate the programming of adult hypertensionpt_BR
dc.relation.ispartofThe Nephron Journalspt_BR
dc.relation.ispartofabbreviationNephronpt_BR
dc.publisher.cityBaselpt_BR
dc.publisher.countrySuiçapt_BR
dc.publisherS. Karger AGpt_BR
dc.date.issued2015-
dc.language.isoengpt_BR
dc.description.volume129pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage283pt_BR
dc.description.lastpage292pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1660-8151pt_BR
dc.identifier.eissn2235-3186pt_BR
dc.identifier.doi10.1159/000377634pt_BR
dc.identifier.urlhttps://www.karger.com/Article/Abstract/377634pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber500868/91-3pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber10/52696-0; 11/17016-1pt_BR
dc.date.available2020-11-20T19:49:46Z-
dc.date.accessioned2020-11-20T19:49:46Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-11-20T19:49:46Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-11-20T19:49:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/352863-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000353721100008pt_BR
dc.creator.orcid0000-0003-2619-3288pt_BR
dc.creator.orcid0000-0002-1196-2606pt_BR
dc.creator.orcid0000-0002-4658-385Xpt_BR
dc.type.formArtigopt_BR
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