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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAbuna, Gabriel Flores-
dc.typeArtigopt_BR
dc.titleCytotoxicity and the effect of cationic peptide fragments against cariogenic bacteria under planktonic and biofilm conditionspt_BR
dc.contributor.authorKreling, P.F.-
dc.contributor.authorAida, K.L.-
dc.contributor.authorMassunari, L.-
dc.contributor.authorCaiaffa, K.S.-
dc.contributor.authorPercinoto, C.-
dc.contributor.authorBedran, T.B.L.-
dc.contributor.authorSpolidorio, D.M.P.-
dc.contributor.authorAbuna, G.F.-
dc.contributor.authorCilli, E.M.-
dc.contributor.authorDuque, C.-
dc.subjectBiofilmespt_BR
dc.subjectCárie dentáriapt_BR
dc.subject.otherlanguageBiofilmspt_BR
dc.subject.otherlanguageDental cariespt_BR
dc.description.abstractThis study evaluated the cytotoxicity and effect of fragments derived from three oral cationic peptides (CP): LL-37, D6-17 and D1-23 against cariogenic bacteria under planktonic and biofilm conditions. For cytotoxicity analysis, two epithelial cell lines were used. The minimum inhibitory concentration and the minimal bactericidal concentration were determined for the CP fragments and the control (chlorhexidine-CHX) against cariogenic bacteria. The fractional inhibitory concentration was obtained for the combinations of CP fragments on Streptococcus mutans. Biofilm assays were conducted with the best antimicrobial CP fragment against S. mutans. The results indicated that D6-17 was not cytotoxic. D1-23, LL-37 and CHX were not cytotoxic in low concentrations. D1-23 presented the best bactericidal activity against S. mutans, S. mitis and S. salivarius. Combinations of CP fragments did not show a synergic effect. D1-23 presented a higher activity against S. mutans biofilm than CHX. It was concluded that D1-23 showed a substantial effect against cariogenic bacteria and low cytotoxicity.pt_BR
dc.relation.ispartofBiofouling: the journal of bioadhesion and biofilm researchpt_BR
dc.relation.ispartofabbreviationBiofoulingpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherTaylor & Francispt_BR
dc.date.issued2016-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume32pt_BR
dc.description.issuenumber9pt_BR
dc.description.firstpage995pt_BR
dc.description.lastpage1006pt_BR
dc.rightsFechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn0892-7014pt_BR
dc.identifier.eissn1029-2454pt_BR
dc.identifier.doi10.1080/08927014.2016.1218850pt_BR
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/08927014.2016.1218850pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2012/192355; 2013/12285-0pt_BR
dc.date.available2020-11-20T19:07:31Z-
dc.date.accessioned2020-11-20T19:07:31Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-11-20T19:07:31Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-10T20:09:38Z : No. of bitstreams: 1 2-s2.0-84988878589.pdf: 3449534 bytes, checksum: 2af8431cc64cd149072198d28320707e (MD5) Bitstreams deleted on 2021-02-10T20:09:57Z: 2-s2.0-84988878589.pdf,. Added 1 bitstream(s) on 2021-02-10T20:10:08Z : No. of bitstreams: 1 2-s2.0-84988878589.pdf: 3449534 bytes, checksum: 2af8431cc64cd149072198d28320707e (MD5)en
dc.description.provenanceMade available in DSpace on 2020-11-20T19:07:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/352853-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordPeptidespt_BR
dc.identifier.source2-s2.0-84988878589pt_BR
dc.creator.orcid0000-0002-9812-488pt_BR
dc.type.formArtigopt_BR
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