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Type: Artigo
Title: Effect of eugenol against streptococcus agalactiae and synergistic interaction with biologically produced silver nanoparticles
Author: Biasi-Garbin, Renata Perugini
Otaguiri, Eliane Saori
Morey, Alexandre Tadachi
da Silva, Mayara Fernandes
Belotto Morguette, Ana Elisa
Contreras Lancheros, Cesar Armando
Kian, Danielle
Eches Perugini, Marcia Regina
Nakazato, Gerson
Duran, Nelson
Nakamura, Celso Vataru
Yamauchi, Lucy Megumi
Yamada-Ogatta, Sueli Fumie
Abstract: Streptococcus agalactiae (group B streptococci (GBS)) is an important infections agent in newborns associated with maternal vaginal colonization. Intrapartumantibiotic prophylaxis in GBS-colonized pregnant women has led to a significant reduction in the incidence of early neonatal infection in various geographic regions. However, this strategy may lead to resistance selecting among GBS, indicating the need for new alternatives to prevent bacterial transmission and even to treat GBS infections. This study reported for the first time the effect of eugenol on GBS isolated from colonized women, alone and in combination with silver nanoparticles produced by Fusarium oxysporum (AgNPbio). Eugenol showed a bactericidal effect against planktonic cells of all GBS strains, and this effect appeared to be time-dependent as judged by the time-kill curves and viability analysis. Combination of eugenol with AgNPbio resulted in a strong synergistic activity, significantly reducing the minimum inhibitory concentration values of both compounds. Scanning and transmission electron microscopy revealed fragmented cells and changes in bacterial morphology after incubation with eugenol. In addition, eugenol inhibited the viability of sessile cells during biofilm formation and in mature biofilms. These results indicate the potential of eugenol as an alternative for controlling GBS infections
Subject: Atividade antibacteriana
Country: Reino Unido
Editor: Hindawi
Rights: Aberto
Identifier DOI: 10.1155/2015/861497
Date Issue: 2015
Appears in Collections:IQ - Artigos e Outros Documentos

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