Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/352831
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampOrsi, Fernanda Loureiro de Andrade-
dc.contributor.authorunicampColella, Marina Pereira-
dc.contributor.authorunicampDe Paula, Erich Vinicius-
dc.contributor.authorunicampVassallo, José-
dc.contributor.authorunicampAnnichino-Bizzacchi, Joyce Maria-
dc.typeArtigopt_BR
dc.titleAcquired thrombotic thrombocytopenic purpura due to antibody-mediated adamts13 deficiency precipitated by a localized castleman's disease: a case reportpt_BR
dc.contributor.authorLopes Benevides, Thais Celi-
dc.contributor.authorOrsi, Fernanda Andrade-
dc.contributor.authorColella, Marina Pereira-
dc.contributor.authorPercout, Priscila de Oliveira-
dc.contributor.authorMoura, Muriel Silva-
dc.contributor.authorDias, Maria Almeida-
dc.contributor.authorLins, Betina Diniz-
dc.contributor.authorde Paula, Erich Vinicius-
dc.contributor.authorVassallo, Jose-
dc.contributor.authorAnnichino-Bizzachi, Joyce-
dc.subjectDisturbios linfoproliferativospt_BR
dc.subjectPúrpura trombocitopênica trombóticapt_BR
dc.subject.otherlanguageLymphoproliferative disorderspt_BR
dc.subject.otherlanguagePurpura, thrombotic thrombocytopenicpt_BR
dc.description.abstractAcquired ADAMTS13 inhibitor causing thrombotic thrombocytopenic purpura (TTP) may be precipitated by some infections, inflammatory diseases or neoplasia. We reported a case of refractory TTP precipitated by a newly diagnosed localized Castleman's disease (CD). TTP was initially treated with plasma exchange and immunosuppressive therapy with corticosteroids; however the treatment failed to promote sustained response. During hospitalization, an abdominal tumor was diagnosed and resected; the histological analysis revealed a CD of hyaline-vascular variant rich stroma. After tumor removal, the patient achieved a long-lasting clinical remission and normalized ADAMTS13 activity. This clinical case describes a novel association of acquired ADAMTS13 inhibitor and CD. The antibody to ADAMTS13 developed along with the systemic manifestation of CD and promptly disappeared after the resection of the tumor. There are reports of neoplasia-associated thrombotic microangiopathy however direct evidence of CD-dependent ADAMTS13 inhibitor had not yet been reportedpt_BR
dc.relation.ispartofPlatelets (London)pt_BR
dc.publisher.cityAbingdonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherTaylor & Francispt_BR
dc.date.issued2015-
dc.language.isoengpt_BR
dc.description.volume26pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage263pt_BR
dc.description.lastpage266pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0953-7104pt_BR
dc.identifier.eissn1369-1635pt_BR
dc.identifier.doi10.3109/09537104.2014.904504pt_BR
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.3109/09537104.2014.904504pt_BR
dc.date.available2020-11-20T16:43:27Z-
dc.date.accessioned2020-11-20T16:43:27Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-11-20T16:43:27Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-11-20T16:43:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/352831-
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000351741700012pt_BR
dc.creator.orcid0000-0002-7908-9073pt_BR
dc.creator.orcid0000-0002-5942-1083pt_BR
dc.creator.orcid0000-0003-1539-7912pt_BR
dc.creator.orcid0000-0002-2192-4865pt_BR
dc.creator.orcid0000-0002-1434-1071pt_BR
dc.type.formRelato de casopt_BR
Appears in Collections:FCM - Artigos e Outros Documentos
HEMO - Artigos e Outros Documentos

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