Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/352824
Type: Artigo
Title: From Conformation to interaction: techniques to explore the Hsp70/hsp90 network
Author: Batista, Fernanda A. H.
Gava, Lisandra M.
Pinheiro, Glyucia M. S.
Ramos, Carlos H. I.
Borges, Julio C.
Abstract: Proteins participate in almost every cell physiological function, and to do so, they need to reach a state that allows its function by folding and/or exposing surfaces of interactions. Spontaneous folding in the cell is in general hindered by its crowded and viscous environment, which favors misfolding and nonspecific and deleterious self-interactions. To overcome this, cells have a system, in which Hsp70 and Hsp90 play a central role to aid protein folding and avoid misfolding. The topics of this review include the biophysical tools used for monitoring protein-ligand and protein-protein interactions and also some important results related to the study of molecular chaperones and heat shock proteins (Hsp), with a focus on the Hsp70/Hsp90 network. The biophysical tools and their use to probe the conformation and interaction of Hsp70 and Hsp90 are briefly reviewed
Subject: Calorimetria
Fluorescência
Country: Emirados Árabes Unidos
Editor: Bentham Science
Rights: Aberto
Identifier DOI: 10.2174/1389203716666150505225744
Address: https://www.eurekaselect.com/131028/article
Date Issue: 2015
Appears in Collections:IQ - Artigos e Outros Documentos

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