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|Title:||From Conformation to interaction: techniques to explore the Hsp70/hsp90 network|
|Author:||Batista, Fernanda A. H.|
Gava, Lisandra M.
Pinheiro, Glyucia M. S.
Ramos, Carlos H. I.
Borges, Julio C.
|Abstract:||Proteins participate in almost every cell physiological function, and to do so, they need to reach a state that allows its function by folding and/or exposing surfaces of interactions. Spontaneous folding in the cell is in general hindered by its crowded and viscous environment, which favors misfolding and nonspecific and deleterious self-interactions. To overcome this, cells have a system, in which Hsp70 and Hsp90 play a central role to aid protein folding and avoid misfolding. The topics of this review include the biophysical tools used for monitoring protein-ligand and protein-protein interactions and also some important results related to the study of molecular chaperones and heat shock proteins (Hsp), with a focus on the Hsp70/Hsp90 network. The biophysical tools and their use to probe the conformation and interaction of Hsp70 and Hsp90 are briefly reviewed|
|Country:||Emirados Árabes Unidos|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
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