Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/352541
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMüller, Guilherme Gubert-
dc.contributor.authorunicampKara-José, Newton-
dc.contributor.authorunicampCastro, Rosane Silvestre de-
dc.typeArtigopt_BR
dc.titleTopical tacrolimus 0.03% as sole therapy in vernal keratoconjunctivitis: a randomized double-masked studypt_BR
dc.contributor.authorMueller, Guilherme Gubert-
dc.contributor.authorJose, Newton Kara-
dc.contributor.authorde Castro, Rosane Silvestre-
dc.subjectCeratoconjuntivitept_BR
dc.subjectConjuntivite alérgicapt_BR
dc.subjectTacrolimopt_BR
dc.subjectAntialérgicospt_BR
dc.subject.otherlanguageKeratoconjunctivitispt_BR
dc.subject.otherlanguageConjunctivitis, Allergicpt_BR
dc.subject.otherlanguageTacrolimuspt_BR
dc.subject.otherlanguageAnti-allergic agentspt_BR
dc.description.abstractThis study sought to evaluate the efficacy of the isolated use of tacrolimus compared with the combined use of tacrolimus and olopatadine for the treatment of severe vernal keratoconjunctivitis (VKC). Twenty-one patients with severe VKC were randomized into two groups: one treated with 0.03% tacrolimus ointment combined with 1% olopatadine ophthalmic solution and the other with 0.03% tacrolimus ointment combined with placebo eye drops. The clinical signs and symptoms were graded from 0 to 3, and the efficacy of treatment was determined by the difference between the score at the beginning of treatment and after 30 days. The clinical impression of improvement as perceived by the evaluator and the self-assessment provided by the patient were scored at day 30 of treatment and compared between the groups.Results:The scores for symptoms decreased between the assessments in both groups (-1.73.9 in the experimental group; -0.6 +/- 1.6 in the control group), with no significant difference between groups (P=0.205). The scores for clinical signs decreased between the assessments in the experimental group (-1.1 +/- 2.7) and increased in the control group (0.3 +/- 0.9) but with no significant differences (P=0.205). There was no significant difference between the groups regarding the self-assessment (P=0.659) and the clinical impression of the evaluator (P=0.387). The isolated use of tacrolimus and the combined use of tacrolimus and olopatadine seems to have the same efficacy, although controlled studies with larger samples are required to confirm this hypothesispt_BR
dc.relation.ispartofEye and Contact Lens: science and clinical practicept_BR
dc.relation.ispartofabbreviationEye Contact Lenspt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.date.issued2014-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume40pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage79pt_BR
dc.description.lastpage83pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1542-2321pt_BR
dc.identifier.eissn1542-233Xpt_BR
dc.identifier.doi10.1097/ICL.0000000000000001pt_BR
dc.identifier.urlhttps://journals.lww.com/claojournal/Abstract/2014/03000/Topical_Tacrolimus_0_03__as_Sole_Therapy_in_Vernal.4.aspxpt_BR
dc.date.available2020-11-19T13:05:26Z-
dc.date.accessioned2020-11-19T13:05:26Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-11-19T13:05:26Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-11-19T13:05:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/352541-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Oftalmologia e Otorrinolaringologiapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000332072900006pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-5481-550Xpt_BR
dc.creator.orcid0000-0002-1040-2391pt_BR
dc.type.formArtigopt_BR
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