Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/352516
Type: Artigo
Title: Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats
Author: Giraldi, G. M.
de Gasp, F. O. D.
Mourao, V. B.
Neves, L. M. G.
Esquisatto, M. A. M.
Alves, A. A.
Rodrigues, R. A. F.
Mazzi, M. V.
dos Santos, G. M. T.
Mendonca, F. A. S.
Abstract: To investigate the effects of hydroalcoholic leaf extract of Mikania glomerata Spreng (Asteraceae) on the activity of Bothrops jararaca snake venom in Wistar rats. Fifty four rats Wistar were divided into six groups of nine animals in each: control treated with saline; control treated with B. jararaca venom; control treated with M. glomerata extract; B. jararaca venom incubated with M. glomerata extract at proportions of 1:1, 1:2, and 1:4. Histopathological and morphometric analysis showed that intradermal administration of snake venom incubated with the hydroalcoholic extract at proportions of 1:1, 1:2 and 1:4 promoted a significant reduction in the number of inflammatory cells and a marked decrease in edema after the third hour. There was also a significant reduction in the intensity of the hemorrhagic halo in animals receiving the snake venom incubated with the extract, with the observation of a progressive and parallel inhibition with increasing proportion of M. glomerata. The Mikania glomerata hydroalcoholic extract exerted effective anti-inflammatory and antihemorrhagic activity against the effects induced by Bothrops jararaca snake venom
Subject: Venenos de serpentes
Plantas medicinais
Mikania
Bothrops
Country: Brasil
Editor: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Rights: Aberto
Identifier DOI: 10.1590/S0102-86502014000100005
Address: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100030
Date Issue: 2014
Appears in Collections:IB - Artigos e Outros Documentos

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