Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/352214
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampRivera Martínez, César Andrés-
dc.contributor.authorunicampAlmeida, Oslei Paes de-
dc.contributor.authorunicampDella Coletta, Ricardo-
dc.typeArtigopt_BR
dc.titleClinicopathological and immunohistochemical evaluation of oral and oropharyngeal squamous cell carcinoma in Chilean populationpt_BR
dc.contributor.authorCésar Rivera-
dc.contributor.authorWilfredo A González-Arriagada-
dc.contributor.authorMarco Loyola-Brambilla-
dc.contributor.authorOslei Paes de Almeida-
dc.contributor.authorRicardo Della Coletta-
dc.contributor.authorBernardo Venegas-
dc.subjectNeoplasias orofaríngeaspt_BR
dc.subject.otherlanguageOropharyngeal Neoplasmspt_BR
dc.description.abstractIn oral and oropharyngeal squamous cell carcinoma (OCSCC and OPSCC) exist an association between clinical and histopathological parameters with cell proliferation, basal lamina, connective tissue degradation and surrounding stroma markers. We evaluated these associations in Chilean patients. A convenience sample of 37 cases of OCSCC (n=16) and OPSCC (n=21) was analyzed clinically (TNM, clinical stage) and histologically (WHO grade of differentiation, pattern of tumor invasion). We assessed the expression of p53, Ki67, HOXA1, HOXB7, type IV collagen (ColIV) and carcinoma-associated fibroblast (α-SMA-positive cells). Additionally we conducted a univariate/bivariate analysis to assess the relationship of these variables with survival rates. Males were mostly affected (56.2% OCSCC, 76.2% OPSCC). Patients were mainly diagnosed at III/IV clinical stages (68.8% OCSCC, 90.5% OPSCC) with a predominantly infiltrative pattern invasion (62.9% OCSCC, 57.1% OPSCC). Significant association between regional lymph nodes (N) and clinical stage with OCSCC-HOXB7 expression (Chi-Square test P < 0.05) was observed. In OPSCC a statistically significant association exists between p53, Ki67 with gender (Chi-Square test P < 0.05). In OCSCC and OPSCC was statistically significant association between ki67 with HOXA1, HOXB7, and between these last two antigens (Pearson’s Correlation test P < 0.05). Furthermore OPSCC-p53 showed significant correlation when it was compared with α-SMA (Kendall’s Tau-c test P < 0.05). Only OCSCC-pattern invasion and OPSCC-primary tumor (T) pattern resulted associated with survival at the end of the follow up period (Chi-Square Likelihood Ratio, P < 0.05). Clinical, histological and immunohistochemical features are similar to seen in other countries. Cancer proliferation markers were associated strongly from each other. Our sample highlights prognostic value of T and pattern of invasion, but the conclusions may be limited and should be considered with caution (small sample). Many cases were diagnosed in the advanced stages of the disease, which suggests that the diagnosis of OCSCC and OPSCC is made latept_BR
dc.relation.ispartofInternational journal of clinical and experimental pathologypt_BR
dc.relation.ispartofabbreviationInt. j. clin. exp. pathol.pt_BR
dc.publisher.cityMadison, WIpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherE-Century Publishing Corporationpt_BR
dc.date.issued2014-
dc.language.isoengpt_BR
dc.description.volume7pt_BR
dc.description.issuenumber9pt_BR
dc.description.firstpage5968pt_BR
dc.description.lastpage5977pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.eissn1936-2625pt_BR
dc.identifier.urlhttp://www.ijcep.com/V7_No9.htmlpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2009/53839-2pt_BR
dc.date.available2020-11-11T23:58:48Z-
dc.date.accessioned2020-11-11T23:58:48Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-11-11T23:58:48Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-11T21:13:58Z : No. of bitstreams: 1 2-s2.0-84911464358.pdf: 1188980 bytes, checksum: 53fa9afc7d2304238e3f6dd728502016 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-11-11T23:58:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/352214-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordSquamous cell carcinomapt_BR
dc.subject.keywordOral cavity cancerpt_BR
dc.subject.keywordTNMpt_BR
dc.subject.keywordPattern of tumor invasionpt_BR
dc.subject.keywordP53pt_BR
dc.subject.keywordKi67pt_BR
dc.subject.keywordHOX genespt_BR
dc.subject.keywordType IV collagenpt_BR
dc.subject.keywordCarcinoma-associated fibroblastpt_BR
dc.identifier.source2-s2.0-84911464358pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-2002-8003pt_BR
dc.creator.orcid0000-0001-5285-3046pt_BR
dc.type.formArtigo originalpt_BR
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