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|Title:||Gastroprotective effects (in rodents) of a flavonoid rich fraction obtained from Syngonanthus macrolepsis|
|Author:||de Almeida, A. B. A.|
Magri, L. D.
Batista, L. M.
Falcao, H. D.
Lima, G. R. D.
Hiruma-Lima, C. A.
dos Santos, L. C.
Brito, A. R. M. S.
|Abstract:||Syngonanthus macrolepis, popularly known in Brazil as sempre-vivas', is a plant from the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. The species contains a variety of constituents, including flavonoids with gastroprotective effect. In this work, a flavonoid-rich fraction (Sm-FRF) obtained from scapes of S.macrolepis was investigated for preventing gastric ulceration in mice and rats. The activity was evaluated in models of induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs and pylorus ligation). The cytoprotective mechanisms of the Sm-FRF in relation to sulfhydryl (SH) groups, nitric oxide (NO) and antioxidant enzymes were also evaluated. The Sm-FRF (100mg/kg, p.o.) significantly reduced gastric injury in all models, and did not alter gastric juice parameters after pylorus ligation. The results indicate significant gastroprotective activity for the Sm-FRF, which probably involves the participation of both SH groups and the antioxidant system. Both are integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors|
|Editor:||John Wiley & Sons|
|Appears in Collections:||IB - Artigos e Outros Documentos|
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