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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAlvares, Lucia Elvira-
dc.contributor.authorunicampSobreira, Debora Rodrigues-
dc.typeArtigopt_BR
dc.titleEvolutionarily conserved morphogenetic movements at the vertebrate head-trunk interface coordinate the transport and assembly of hypopharyngeal structurespt_BR
dc.contributor.authorLours-Calet, Corinne-
dc.contributor.authorAlvares, Lucia E.-
dc.contributor.authorEl-Hanfy, Amira S.-
dc.contributor.authorGandesha, Saniel-
dc.contributor.authorWalters, Esther H.-
dc.contributor.authorSobreira, Debora Rodrigues-
dc.contributor.authorWotton, Karl R.-
dc.contributor.authorJorge, Erika C.-
dc.contributor.authorLawson, Jennifer A.-
dc.contributor.authorLewis, A. Kelsey-
dc.contributor.authorTada, Masazumi-
dc.contributor.authorSharpe, Colin-
dc.contributor.authorKardon, Gabrielle-
dc.contributor.authorDietrich, Susanne-
dc.subjectCrista neuralpt_BR
dc.subjectPeixe-zebrapt_BR
dc.subject.otherlanguageNeural crestpt_BR
dc.subject.otherlanguageZebrafishpt_BR
dc.description.abstractThe vertebrate head trunk interface (occipital region) has been heavily remodelled during evolution, and its development is still poorly understood. In extant jawed vertebrates, this region provides muscle precursors for the throat and tongue (hypopharyngeal/hypobranchial/hypoglossal muscle precursors, HMP) that take a stereotype path rostrally along the pharynx and are thought to reach their target sites via active migration. Yet, this projection pattern emerged in jawless vertebrates before the evolution of migratory muscle precursors. This suggests that a so far elusive, more basic transport mechanism must have existed and may still be traceable today. Here we show for the first time that all occipital tissues participate in well-conserved cell movements. These cell movements are spearheaded by the occipital lateral mesoderm and ectoderm that split into two streams. The rostrally directed stream projects along the floor of the pharynx and reaches as far rostrally as the floor of the mandibular arch and outflow tract of the heart. Notably, this stream leads and engulfs the later emerging HMP, neural crest cells and hypoglossal nerve. When we (i) attempted to redirect hypobranchial/hypoglossal muscle precursors towards various attractants, (ii) placed non-migratory muscle precursors into the occipital environment or (iii) molecularly or (iv) genetically rendered muscle precursors non-migratory, they still followed the trajectory set by the occipital lateral mesoderm and ectoderm. Thus, we have discovered evolutionarily conserved morphogenetic movements, driven by the occipital lateral mesoderm and ectoderm, that ensure cell transport and organ assembly at the head trunk interfacept_BR
dc.relation.ispartofDevelopmental Biologypt_BR
dc.relation.ispartofabbreviationDev. Biol.pt_BR
dc.publisher.cityMaryland Heights, MOpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherAcademic Presspt_BR
dc.date.issued2014-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume390pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage231pt_BR
dc.description.lastpage246pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0012-1606pt_BR
dc.identifier.eissn1095-564Xpt_BR
dc.identifier.doi10.1016/j.ydbio.2014.03.003pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0012160614001389pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2006/05892-3pt_BR
dc.date.available2020-11-09T17:51:50Z-
dc.date.accessioned2020-11-09T17:51:50Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-11-09T17:51:50Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-16T16:52:53Z : No. of bitstreams: 1 000335540300013.pdf: 4303572 bytes, checksum: dfb708e2fc5efdc3fdef366c0cde02bb (MD5)en
dc.description.provenanceMade available in DSpace on 2020-11-09T17:51:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/352040-
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.identifier.source000335540300013pt_BR
dc.creator.orcid0000-0002-2229-8966pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigopt_BR
dc.description.sponsorNoteGuy's and St. Thomas' Charitable Foundation; Biotechnology and Biological Sciences Research Council (BBSRC); European Union (EU); UoP Faculty of Sciencept_BR
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