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Type: Artigo
Title: Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies: Analysis of the control arm of PATRICIA
Author: Castellsagué, Xavier
Naud, Paulo
Chow, Song-Nan
Wheeler, Cosette M.
Germar, Maria Julieta V.
Lehtinen, Matti
Paavonen, Jorma
Jaisamrarn, Unnop
Garland, Suzanne M.
Salmerón, Jorge
Apter, Dan
Kitchener, Henry
Teixeira, Julio C.
Skinner, S. Rachel
Limson, Genara
Szarewski, Anne
Romanowski, Barbara
Aoki, Fred Y.
Schwarz, Tino F.
Poppe, Willy A. J.
Bosch, F. Xavier
Carvalho, Newton S. de
Peters, Klaus
Tjalma, Wiebren A. A.
Safaeian, Mahboobeh
Raillard, Alice
Descamps, Dominique
Struyf, Frank
Dubin, Gary
Rosillon, Dominique
Baril, Laurence
Abstract: Background. We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681). Methods. Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]). Results. High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lower risk of incident and persistent infection, atypical squamous cells of undetermined significance or greater (ASCUS+), and cervical intraepithelial neoplasia grades 1/2 or greater (CIN1+, CIN2+). For HPV-18, although seropositivity was associated with lower risk of ASCUS+ and CIN1+, no association between naturally acquired antibodies and infection was demonstrated. Naturally acquired HPV-16 antibody levels of 371 (95% confidence interval [CI], 242-794), 204 (95% CI, 129-480), and 480 (95% CI, 250-5756) EU/mL were associated with 90% reduction of incident infection, 6-month persistent infection, and ASCUS+, respectively. Conclusions. Naturally acquired antibodies to HPV-16, and to a lesser extent HPV-18, are associated with some reduced risk of subsequent infection and cervical abnormalities associated with the same HPV type
Subject: Papillomaviridae
Country: Estados Unidos
Editor: Oxford University Press
Rights: Fechado
Identifier DOI: 10.1093/infdis/jiu139
Date Issue: 2014
Appears in Collections:FCM - Artigos e Outros Documentos

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