Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/351908
Type: Artigo
Title: Two polyphenol-rich brazilian fruit extracts protect from diet-induced obesity and hepatic steatosis in mice
Author: Ballard, Cíntia Reis
Santos, Elisvânia Freitas dos
Dubois, Marie-Julie
Pilon, Geneviève
Cazarin, Cinthia Baú Betim
Maróstica Junior, Mário Roberto
Marette, Andre
Abstract: Consumption of polyphenol-rich food is associated with better metabolic health. Tucum-do-Pantanal (Bactris setosa Mart) and taruma-do-cerrado (Vitex cymosa Bertero ex Spreng) are underexploited native Brazilian fruits with an important source of phytochemicals. In this study, we assessed the effects of 100 mg kg−1 tucum (TPE) and taruma (TCE) extracts on diet-induced obesity (DIO) C57BL/6J mice. After 8 weeks of daily treatment, TPE and TCE were found to significantly prevented the diet-induced body weight gain and fully protected against hepatic steatosis associated with a tendency to stimulate hepatic AMPK phosphorylation. TPE reduced visceral obesity and improved glucose metabolism as revealed by an improvement of the insulin tolerance test, a reduction in the insulin fasting level, and a decreased glucose-induced hyperinsulinemia during an oral glucose tolerance test. TPE and TCE showed promising effects on the treatment of obesity and NAFLD, furthermore, TPE on insulin resistance.
Subject: Obesidade
Fígado gorduroso
Polifenóis
Country: Reino Unido
Editor: Royal Society of Chemistry
Rights: Fechado
Identifier DOI: 10.1039/D0FO01912G
Address: https://pubs.rsc.org/en/content/articlelanding/2020/FO/D0FO01912G
Date Issue: 2020
Appears in Collections:FEA - Artigos e Outros Documentos

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