Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/351319
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFigueiredo, Valeria Nasser-
dc.contributor.authorunicampDemacq, Caroline-
dc.contributor.authorunicampMartins, Luiz Claudio-
dc.contributor.authorunicampYugar Toledo, Juan Carlos-
dc.contributor.authorunicampMoreno Junior, Heitor-
dc.typeArtigopt_BR
dc.titleMDR-1 C3435T polymorphism may affect blood pressure in resistant hypertensive patients independently of its effects on aldosterone releasept_BR
dc.contributor.authorRiccardo Lacchini-
dc.contributor.authorValéria N Figueiredo-
dc.contributor.authorCaroline Demacq-
dc.contributor.authorFernanda B Coeli-Lacchini-
dc.contributor.authorLuís C Martins-
dc.contributor.authorJuan Yugar-Toledo-
dc.contributor.authorAntonio Coca-
dc.contributor.authorJose E Tanus-Santos-
dc.contributor.authorHeitor Moreno Jr-
dc.subjectAldosteronapt_BR
dc.subject.otherlanguageAldosteronept_BR
dc.description.abstractAldosterone increases plasma volume and may be involved with resistant hypertension. P-glycoprotein is a transporter involved in the distribution and disposition of aldosterone, and is encoded by the MDR-1 gene. MDR-1 has functional polymorphisms that may affect P-glycoprotein expression. We hypothesized that the C3435T polymorphism in MDR-1 could be associated with resistant hypertension and with changes in hypertension-related parameters. We studied 105 healthy volunteers, 137 hypertensive patients responsive to treatment, and 83 resistant hypertensive patients. While we found no association of C3435T genotypes with resistance to treatment (p = 0.31), C allele was associated with hypertension (p = 0.03). Furthermore, the CC genotype was associated with higher systolic blood pressure (p < 0.01 for both daytime and nighttime, respectively) and diastolic blood pressure (p < 0.01 for both daytime and nighttime, respectively). This effect was probably independent of aldosterone, as we found no differences in aldosterone plasma levels, nor in pulse wave velocity (PVW) between the genotypes groups (p = 0.77 and p = 0.48, respectively). Our results show an association of C3435T with hypertension and with blood pressure levels in resistant hypertensive subjectspt_BR
dc.relation.ispartofJournal of the renin-angiotensin-aldosterone systempt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherSagept_BR
dc.date.issued2014-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume15pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage170pt_BR
dc.description.lastpage176pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn1470-3203pt_BR
dc.identifier.eissn1752-8976pt_BR
dc.identifier.doi10.1177/1470320312466124pt_BR
dc.identifier.urlhttps://journals.sagepub.com/doi/10.1177/1470320312466124pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2020-10-20T09:13:18Z-
dc.date.accessioned2020-10-20T09:13:18Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-10-20T09:13:18Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-11T21:11:55Z : No. of bitstreams: 1 2-s2.0-84902137965.pdf: 210579 bytes, checksum: b7dc5f629ab8632203071f8c164ef073 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-10-20T09:13:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/351319-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordBlood pressurept_BR
dc.subject.keywordC3435T polymorphismpt_BR
dc.subject.keywordMDR-1 genept_BR
dc.subject.keywordP-glycoproteinpt_BR
dc.subject.keywordResistant hypertensionpt_BR
dc.identifier.source2-s2.0-84902137965pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-2920-2162pt_BR
dc.creator.orcid0000-0001-6583-6536pt_BR
dc.creator.orcid0000-0001-6330-697Xpt_BR
dc.type.formArtigopt_BR
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