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Type: Artigo
Title: MDR-1 C3435T polymorphism may affect blood pressure in resistant hypertensive patients independently of its effects on aldosterone release
Author: Riccardo Lacchini
Valéria N Figueiredo
Caroline Demacq
Fernanda B Coeli-Lacchini
Luís C Martins
Juan Yugar-Toledo
Antonio Coca
Jose E Tanus-Santos
Heitor Moreno Jr
Abstract: Aldosterone increases plasma volume and may be involved with resistant hypertension. P-glycoprotein is a transporter involved in the distribution and disposition of aldosterone, and is encoded by the MDR-1 gene. MDR-1 has functional polymorphisms that may affect P-glycoprotein expression. We hypothesized that the C3435T polymorphism in MDR-1 could be associated with resistant hypertension and with changes in hypertension-related parameters. We studied 105 healthy volunteers, 137 hypertensive patients responsive to treatment, and 83 resistant hypertensive patients. While we found no association of C3435T genotypes with resistance to treatment (p = 0.31), C allele was associated with hypertension (p = 0.03). Furthermore, the CC genotype was associated with higher systolic blood pressure (p < 0.01 for both daytime and nighttime, respectively) and diastolic blood pressure (p < 0.01 for both daytime and nighttime, respectively). This effect was probably independent of aldosterone, as we found no differences in aldosterone plasma levels, nor in pulse wave velocity (PVW) between the genotypes groups (p = 0.77 and p = 0.48, respectively). Our results show an association of C3435T with hypertension and with blood pressure levels in resistant hypertensive subjects
Subject: Aldosterona
Country: Reino Unido
Editor: Sage
Rights: Fechado
Identifier DOI: 10.1177/1470320312466124
Date Issue: 2014
Appears in Collections:FCM - Artigos e Outros Documentos

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