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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampKoolen, Hector Henrique Ferreira-
dc.typeArtigopt_BR
dc.titlePhytochemical study of the alkaloidal fractions of unonopsis duckei R. E. Fr. guided by electrospray ionisation ion-trap tandem mass spectrometrypt_BR
dc.contributor.authorPinheiro, M. L. B.-
dc.contributor.authorFerreira, A. G.-
dc.contributor.authorCosta, E. V.-
dc.contributor.authorVendramin, M. E.-
dc.contributor.authorda Silva, F. M. A.-
dc.contributor.authorKoolen, H. H. F.-
dc.contributor.authorde Souza, A. D. L.-
dc.contributor.authorBarison, A.-
dc.subjectAlcaloidespt_BR
dc.subjectFitoquímicospt_BR
dc.subject.otherlanguageAlkaloidspt_BR
dc.subject.otherlanguagePhytochemicalspt_BR
dc.description.abstractThe Unonopsis genus is a promising source of aporphinoid alkaloids, substances with great biological potential. These alkaloids have a well-defined mass spectrometry fragmentation pattern that, together with previous phytochemical knowledge, can guide the isolation of alkaloids not yet described for the genus. Isolate substances not yet described in the Unonopsis genus, guided by alkaloidal profile analyses of stem barks, twigs and leaves of Unonopsis duckei using electrospray ionisation ion-trap tandem mass spectrometry (ESI-IT/MSn). Methanolic extracts from stem barks, twigs and leaves were submitted to a liquid-liquid, acid-base partitioning treatment to obtain the alkaloidal fractions. These fractions were analysed by direct infusion into an ESI-IT/MSn system. The major alkaloids observed for each fraction were submitted to fragmentation analysis. The MS fragmentation patterns revealed the presence of alkaloids previously reported for Annonaceae, including nornuciferine, anonaine, asimilobine, liriodenine and lysicamine, known for the Unonopsis genus, as well as others that were not yet described for this genus. In this way, the proaporphine alkaloid glaziovine was isolated, as well as a mixture of the aporphine alkaloids glaucine and norglaucine, all described for the first time in the Unonopsis genus. Mass spectrometry monitoring was fundamental to prioritise the isolation of substances not yet identified for the Unonopsis genus, dismissing known compounds and simplifying the phytochemical study. Copyright (c) 2013 John Wiley & Sons, Ltd. The MS monitoring of the alkaloidal fractions of the Unonopsis duckei was fundamental to prioritise the isolation of substances not yet identified for the Unonopsis genus, dismissing known compounds and simplifying the phytochemical study. The presence of alkaloids previously reported for Annonaceae family, nornuciferine (3), anonaine (4), asimilobine (5), lysicamine (6) and liriodenine (7) was detected. The proaporphine alkaloid glaziovine (1) and the aporphine alkaloids glaucine (2a) and norglaucine (2b) are described for the first time in the Unonopsis genuspt_BR
dc.relation.ispartofPhytochemical analysispt_BR
dc.relation.ispartofabbreviationPhytochem analpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherJohn Wiley & Sonspt_BR
dc.date.issued2014-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume25pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage45pt_BR
dc.description.lastpage49pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0958-0344pt_BR
dc.identifier.eissn1099-1565pt_BR
dc.identifier.doi10.1002/pca.2458pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/pca.2458pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFINANCIADORA DE ESTUDOS E PROJETOS - FINEPpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO AMAZONAS - FAPEAMpt_BR
dc.date.available2020-10-15T18:48:38Z-
dc.date.accessioned2020-10-15T18:48:38Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-10-15T18:48:38Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-16T16:52:27Z : No. of bitstreams: 1 000328554500005.pdf: 548929 bytes, checksum: 75159998e1a7b6708655bdc47da89763 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-10-15T18:48:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/351194-
dc.contributor.unidadeInstituto de Químicapt_BR
dc.subject.keywordGlaucinept_BR
dc.subject.keywordGlaziovinept_BR
dc.identifier.source000328554500005pt_BR
dc.creator.orcid0000-0002-0181-348Xpt_BR
dc.type.formArtigopt_BR
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