Please use this identifier to cite or link to this item:
Type: Artigo
Title: Obesity and cytokines in childhood-onset systemic lupus erythematosus
Author: Postal, M.
Sinicato, N. A.
Pelicari, K. D.
Marini, R.
Peres, F. A.
dos Santos, A. D.
Appenzeller, S.
Ramos, C. D.
Abstract: In systemic lupus erythematosus (SLE), atherosclerosis is attributed to traditional and lupus related risk factors, including metabolic syndrome (MetS), obesity, and inflammation. Objective. To evaluate the association between obesity, measures of body fat content, serum tumor necrosis factor alpha (TNF-alpha), and interleukin (IL)-6 and -10 levels in childhood-onset SLE (cSLE). We screened consecutive cSLE patients followed up in the Pediatric Rheumatology Outpatient Clinic of the State University of Campinas. cSLE patients were assessed for disease and damage. Obesity was definite as body mass index (BMI) >= 30 kg/m(2). Serum TNF-alpha, IL-6, and IL-10 levels were measured by ELISA. Dual-energy X-ray absorptiometry was used to determine total fat mass, lean mass, and percent of body fat. We included 52 cSLE patients and 52 controls. cSLE patients had higher serum TNF-alpha (P = 0.004), IL-6 (P = 0.002), and IL-10 (P < 0.001) levels compared to controls. We observed higher serum TNF-alpha (P = 0.036) levels in cSLE patients with obesity. An association between serum TNF-alpha levels and body fat percent (P = 0.046) and total fat mass on trunk region (P = 0.035) was observed. Serum TNF-alpha levels were associated with obesity and body fat content in cSLE. Our finding suggests that obesity may contribute to the increase of serum TNF-alpha levels in cSLE
Subject: Fator de necrose tumoral alfa
Resistência à insulina
Tecido adiposo
Country: Reino Unido
Editor: Hindawi
Rights: Aberto
Identifier DOI: 10.1155/2014/162047
Date Issue: 2014
Appears in Collections:FCM - Artigos e Outros Documentos
HC - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000332875400001.pdf1.32 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.