Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/351078
Type: Artigo
Title: Quality of sweat test (ST) based on the proportion of sweat sodium (Na) and sweat chloride (Cl) as diagnostic parameter of cystic fibrosis: are we on the right way?
Author: Faria, Alethéa Guimarães
Marson, Fernando Augusto Lima
Gomez, Carla Cristina de Souza
Ribeiro, Maria Ângela Gonçalves de Oliveira
Morais, Lucas Brioschi
Servidoni, Maria de Fátima
Bertuzzo, Carmen Sílvia
Sakano, Eulália
Goto, Maura
Paschoal, Ilma Aparecida
Pereira, Mônica Corso
Hessel, Gabriel
Levy, Carlos Emílio
Toro, Adyléia Aparecida Dalbo Contrera
Peixoto, Andressa Oliveira
Simões, Maria Cristina Ribeiro
Lomazi, Elizete Aparecida
Nogueira, Roberto José Negrão
Ribeiro, Antônio Fernando
Ribeiro, José Dirceu
Abstract: To assess the quality of sweat test (ST) based on the proportion of sweat sodium and sweat chloride as diagnostic parameter of cystic fibrosis (CF). A retrospective study of 5,721 sweat samples and subsequent descriptive analysis were carried out. The test was considered "of good quality" (correct) when: (i) sweat chloride was lower than 60 mEq/L, and sweat sodium was higher than sweat chloride; (ii) sweat chloride was higher than 60 mEq/L, and sweat sodium was lower than sweat chloride. The study included 5,692/5,721 sweat samples of ST which had been requested due to clinical presentations compatible with CF and/or neonatal screenings with altered immunoreactive trypsinogen values. Considering the proportion of sweat sodium and sweat chloride as ST quality parameter, the test was performed correctly in 5,023/5,692 (88.2 %) sweat samples. The sweat chloride test results were grouped into four reference ranges for chloride (i) chloride >= 30 mEq/L: 3,651/5,692 (64.1 %); (ii) chloride < 30 mEq/L to < 40 mEq/L: 652/5,692 (11.5 %); (iii) >= 40 mEq/L to < 60 mEq/L: 673/5,692 (11.8 %); (iv) >= 60 mEq/L: 716/5,692 (12.6 %). In the comparative analysis, there was no association between ST quality and: (i) symptoms to indicate a ST [respiratory (p = 0.084), digestive (p = 0.753), nutritional (p = 0.824), and others (p = 0.136)], (ii) sweat weight (p = 0.416). However, there was a positive association with: (i) gender, (ii) results of ST (p < 0.001), (iii) chloride/sodium ratio (p < 0.001), (iv) subject's age at the time of ST [grouped according to category (p < 0.001) and numerical order (p < 0.001)]. For the subset of 169 patients with CF and two CFTR mutations Class I, II and/or III, in comparative analysis, there was a positive association with: (i) sweat chloride/sodium ratio (p < 0.001), (ii) sweat chloride values (p = 0.047), (iii) subject's age at the time of the ST grouped by numerical order (p = 0.001). Considering that the quality of ST can be assessed by levels of sweat sodium and sweat chloride, an increasing number of low-quality tests could be observed in our sweat samples. The quality of the test was associated with important factors, such as gender, CF diagnosis, and subjects' age
Subject: Fibrose cística
Country: Reino Unido
Editor: BioMed Central
Rights: Aberto
Identifier DOI: 10.1186/s13000-016-0555-6
10.1186/s13000-017-0611-x
Address: https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-016-0555-6
https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-017-0611-x
Date Issue: 2016
Appears in Collections:FCM - Artigos e Outros Documentos

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