Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/351044
Type: Artigo
Title: Low ten-eleven-translocation 2 (TET2) transcript level is independent of TET2 mutation in patients with myeloid neoplasms
Author: Scopim-Ribeiro, Renata
Machado-Neto, João Agostinho
Melo Campos, Paula de
Niemann, Fernanda Soares
Lorand-Metze, Irene
Costa, Fernando Ferreira
Olalla Saad, Sara Teresinha
Traina, Fabiola
Abstract: New sequencing technologies have enabled the identification of mutations in Ten-eleven-translocation 2 (TET2), an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) in myeloid neoplasms. We have recently identified reduced TET2 mRNA expression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), which is associated with a poor overall survival in MDS. We herein aimed to investigate TET2 mutations and their impact on TET2 expression in a cohort of patients with myeloid neoplasms, including MDS and AML patients. Findings: TET2 mutations were observed in 8 out of 19 patients (42 %) with myeloid neoplasms. The TET2 expression profile was similar between in wild type and in TET2 mutated patients. Conclusion: Our results suggest that TET2 expression is reduced in MDS/AML patients, independently of mutational status
Subject: Síndromes mielodisplásicas
Leucemia mielóide aguda
Country: Reino Unido
Editor: BioMed Central
Rights: Aberto
Identifier DOI: 10.1186/s13000-016-0476-4
Address: https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-016-0476-4
Date Issue: 2016
Appears in Collections:FCM - Artigos e Outros Documentos
HEMO - Artigos e Outros Documentos

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