Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/351025
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMadureira de Medeiros, Tiago Daniel-
dc.contributor.authorunicampAlexandrino, Thaís Dolfini-
dc.contributor.authorunicampPastore, Glaucia Maria-
dc.contributor.authorunicampBicas, Juliano Lemos-
dc.typeArtigopt_BR
dc.titleExtraction and purification of limonene-1,2-diol obtained from the fungal biotransformation of limonenept_BR
dc.contributor.authorMedeiros, Tiago Daniel Madureira de-
dc.contributor.authorAlexandrino, Thaís Dolfini-
dc.contributor.authorPastore, Gláucia Maria-
dc.contributor.authorBicas, Juliano Lemos-
dc.subjectAtividade biológicapt_BR
dc.subject.otherlanguageBiological activitypt_BR
dc.description.abstractR-(+)-limonene is the main component of the orange peel oil, which is available in large amounts, at low cost, and can be employed in biotransformation processes as a precursor of different value-added aroma compounds. Limonene-1,2-diol is one of the oxyfunctionalyzed counterparts of limonene that can be obtained from the biotransformation process, but its biological properties and applications are still little investigated in literature. Thus, we aimed to study the recovery and purification of limonene-1,2-diol obtained from fungal biotransformation, which is an essential step for further investigations. First, liquid-liquid extractions were performed to select the most appropriate solvent, extraction time, and extracting material (whole fermented broth or supernatant) for recovering limonene-1,2-diol. Subsequently, sequential extractions with different solvents were considered for recovering larger amounts of limonene-1,2-diol as well as for removing the residual limonene. Finally, Open Column Chromatography procedures were evaluated for purifying limonene-1,2-diol originating from a limonene:limonene-1,2-diol mixture. According to the results, ethyl acetate was the most adequate solvent for recovering limonene-1,2-diol, and equilibrium was quickly reached (20 s in vortex). The extraction of the supernatant was repeated twice with hexane, followed by two sequential extractions with ethyl acetate, and was found to be the most suitable process for recovering limonene-1,2-diol in higher yields and purities. In addition, a silica-gel column chromatography was used for separating limonene from limonene-1,2-diol, but this procedure was deemed unnecessary, since better recovery and purification yields were obtained from the liquid-liquid extraction. The processes described in our study may be useful for researchers working with limonene-1,2-diol or other oxidized monoterpenoid as well as with downstream processing of biotransformation productspt_BR
dc.relation.ispartofSeparation and purification technologypt_BR
dc.relation.ispartofabbreviationSep. purif. technol.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2021-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume254pt_BR
dc.rightsFechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn1383-5866pt_BR
dc.identifier.eissn1873-3794pt_BR
dc.identifier.doi10.1016/j.seppur.2020.117683pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1383586620321572pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber134616/2016-2; 400411/2016-4pt_BR
dc.description.sponsordocumentnumber23038.000795/2018-61pt_BR
dc.description.sponsordocumentnumber2016/21619-7pt_BR
dc.date.available2020-10-14T16:54:33Z-
dc.date.accessioned2020-10-14T16:54:33Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2020-10-14T16:54:33Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-10-14T16:54:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2021en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/351025-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Ciência de Alimentospt_BR
dc.contributor.departmentDepartamento de Ciência de Alimentospt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.subject.keywordColletotrichum nymphaeapt_BR
dc.subject.keywordColumn chromatographypt_BR
dc.subject.keywordSolvent extractionpt_BR
dc.identifier.source2-s2.0-85090337608pt_BR
dc.creator.orcid0000-0003-4561-9352pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-9631-0158pt_BR
dc.creator.orcid0000-0002-5252-4004pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid117683pt_BR
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