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Type: Artigo
Title: Acmella oleracea and achyrocline satureioides as sources of natural products in topical wound care
Author: Yamane, Lais Thiemi
Paula, Eneida de
Jorge, Michelle Pedroza
Freitas-Blanco, Verônica Santana de
Montanari Junior, Ílio
Figueira, Glyn Mara
Anholeto, Luís Adriano
Oliveira, Patricia Rosa de
Rodrigues, Rodney Alexandre Ferreira
Abstract: The Brazilian forests have one of the world's biggest biodiversities. Achyrocline satureioides (macela) and Acmella oleracea (jambu) are native species from Brazil with a huge therapeutic potential, with proved anti-inflammatory and anesthetic action, respectively. The jambu's crude extract after depigmentation with activated charcoal and macela's essential oil were incorporated in a film made with hydroxyethyl cellulose. Those films were evaluated by mechanical test using a texturometer and anti-inflammatory and anesthetic activities by in vivo tests: wound healing and antinociceptive. The film containing the highest concentration of depigmented jambu's extract and macela's essential oil obtained an anesthesia time of 83.6 (+/- 28.5) min longer when compared with the positive control EMLA (R); the same occurred with the wound healing test; the film containing the highest concentration had a higherwound contraction (62.0%+/- 12.1) compared to the positive control allantoin and the histopathological analysis demonstrated that it increases collagen synthesis and epidermal thickening. The results demonstrate that the films have a potential use in skin wounds, pressure sore, and infected surgical wounds treatment
Subject: Ferimentos e lesões - Tratamento
Country: Reino Unido
Editor: Hindawi
Rights: Aberto
Identifier DOI: 10.1155/2016/3606820
Date Issue: 2016
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos
CPQBA - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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