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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampPalei, Ana Carolina Taveiros-
dc.contributor.authorunicampTanus-Santos, Jose Eduardo-
dc.typeArtigopt_BR
dc.titleCorrelations between circulating levels of adipokines and anti-angiogenic factors in women with BMI < 30 and a late-onset preeclampsiapt_BR
dc.contributor.authorEleuterio, N. M.-
dc.contributor.authorTanus-Santos, J. E.-
dc.contributor.authorCavalli, R. C.-
dc.contributor.authorPalei, A. C. T.-
dc.contributor.authorSandrim, V. C.-
dc.contributor.authorMachado, J. S. R.-
dc.subjectAdiponectinapt_BR
dc.subjectNeovascularizaçãopt_BR
dc.subject.otherlanguageAdiponectinpt_BR
dc.subject.otherlanguageNeovascularizationpt_BR
dc.description.abstractPreeclampsia (PE) is a pregnancy-specific disease, directly related to high rates of maternal-fetal morbidity and mortality worldwide. Upregulation of anti-angiogenic factors (soluble fms-like tyrosine kinase-1; sFLT-1 and soluble endoglin; sENG) have been suggested to trigger the maternal endothelial dysfunction observed in PE. Studies focusing on the role of adiponectin and leptin, in normal pregnancy as well as in complicated pregnancies, have revelated interesting findings due to the vascular actions of such adipokines. The aims of this study were to compare plasma concentrations of the adiponectin, leptin, sENG and sFLT-1 in preeclamptic (PE, n = 27) and healthy pregnant (HP, n = 36) and to evaluate possible correlations among these adipokines and anti-angiogenic factors. There were significant increases in all biomarkers in PE compared to HP (all p<0.05). In PE group, there were positive strong correlations among adiponectin and leptin with sFLT-1 (r = 0.85 and r = 0.47, respectively) and sEng (r = 0.74 and r = 0.56, respectively). Moreover, we observed significantly correlation among body mass index (BMI) with adiponectin (r = -0.40) and with leptin (r = 0.51) in HP, but not in PE. Moreover, while a negative correlation between sFLT-1 and BMI (r = -0.60) was found in PE, no correlation was observed regarding sEng and BMI. In summary, our findings suggest the existence of a compensatory mechanism that occurs in an attempt to correct this angiogenic imbalance in order to restore the fetal developmentpt_BR
dc.relation.ispartofHypertension in Pregnancypt_BR
dc.relation.ispartofabbreviationHypertens Pregnancypt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherTaylor & Francispt_BR
dc.date.issued2014-
dc.language.isoengpt_BR
dc.description.volume33pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage72pt_BR
dc.description.lastpage80pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1064-1955pt_BR
dc.identifier.eissn1525-6065pt_BR
dc.identifier.doi10.3109/10641955.2013.837174pt_BR
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.3109/10641955.2013.837174pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS - FAPEMIGpt_BR
dc.date.available2020-10-13T14:45:39Z-
dc.date.accessioned2020-10-13T14:45:39Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-10-13T14:45:39Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-06-30T17:36:52Z : No. of bitstreams: 1 000329131200007.pdf: 247080 bytes, checksum: 308c95d11f7d66089d2d41e2201017ac (MD5)en
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dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/350904-
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000329131200007pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-9945-9633pt_BR
dc.type.formArtigopt_BR
dc.description.sponsorNoteInstituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte (IEP-SCBH)pt_BR
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