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dc.contributor.authorunicampMelo, Mônica Barbosa de-
dc.titleGSTT1, GSTM1, and GSTP1 polymorphisms as a prognostic factor in women with breast cancerpt_BR
dc.contributor.authorRodrigues, F. F. O.-
dc.contributor.authorde Melo, M. B.-
dc.contributor.authorOliveira, A. L.-
dc.contributor.authorRozenowicz, R. L.-
dc.contributor.authordos Santos, R. E.-
dc.subjectNeoplasias da mamapt_BR
dc.subjectPolimorfismo (Genética)pt_BR
dc.subject.otherlanguageBreast neoplasmspt_BR
dc.subject.otherlanguageGenetic polymorphismspt_BR
dc.description.abstractThe glutathione S-transferase (GST) family comprises phase-II cellular detoxification enzymes that catalyze the conjugation of chemotherapy drugs to glutathione and act on the apoptotic pathway. The aim of this study was to determine whether polymorphisms of the GSTT1, GSTM1, and GSTP1 genes are associated with different rates of overall survival (OS) and disease-free survival (DFS) after neoadjuvant chemotherapy in the management of locally advanced breast cancer, using either simple or combined analyses, and in relation to the post-therapy axillary lymph node status. Forty women with invasive ductal carcinoma of the breast submitted to neoadjuvant chemotherapy with 5-fluorouracil, epirubicin, and cyclophosphamide were genotyped for GSTT1, GSTM1, and GSTP1. Comparisons were performed for the three genes, either isolated or in pairs, in polymorphic or wild-type combinations. Finally, the OS and DFS of patients were analyzed with respect to axillary lymph node status and with respect to wild-type or polymorphic presentations of each gene. No statistically significant difference in OS and DFS was evident between women with wildtype or polymorphic forms of the genes, either isolated or in pairs, after neoadjuvant chemotherapy. By contrast, after treatment, lymph node-negative women had better OS and DFS only in the presence of polymorphisms of GSTP1, and improved DFS only in the presence of the polymorphic types of GSTT1 and GSTM1 compared to women with positive lymph nodes. The presence of polymorphic forms of GSTP1, GSTM1, and GSTT1 was crucial to conferring better OS and DFS among women with negative axillary lymph nodespt_BR
dc.relation.ispartofGenetics and molecular researchpt_BR
dc.relation.ispartofabbreviationGenet. mol. res.pt_BR
dc.publisher.cityRibeirão Preto, SPpt_BR
dc.description.provenanceSubmitted by Cintia Oliveira de Moura ( on 2020-10-09T15:54:58Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-16T16:52:23Z : No. of bitstreams: 1 000336729500020.pdf: 786946 bytes, checksum: 3a31d7ba41521a64562210ac6b6e2262 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-10-09T15:54:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.contributor.unidadeCentro de Biologia Molecular e Engenharia Genéticapt_BR
dc.subject.keywordDrug therapypt_BR
dc.subject.keywordGlutathione transferasept_BR
dc.type.formArtigo de pesquisapt_BR
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