Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/350826
Type: Artigo
Title: Brazilian berry extract (Myrciaria jaboticaba): a promising therapy to minimize prostatic inflammation and oxidative stress
Author: Lamas, Celina A.
Kido, Larissa A.
Hermes, Tulio A.
Nogueira-Lima, Ellen
Minatel, Elaine
Collares-Buzato, Carla B.
Marostica Junior, Mario R.
Cagnon, Valeria H. A.
Abstract: Brazilian berry is a fruit popularly known as "Jaboticaba," rich in bioactive compounds with antioxidant and anti-inflammatory properties. Senescence and overweight are increasing worldwide and are considered risk factors to prostatic pathogenesis mainly due to oxidative and inflammatory processes induction. Thus, this study aimed to evaluate the effect of two increasing doses of the patented jaboticaba peel extract (PJE) on oxidative-stress and inflammation in the prostate of aging or high-fat-fed aging mice. PJE and/or high-fat diet (HFD) treatments started with 11-month-old mice and lasted 60 days. The levels or the immunoexpression of different inflammatory (nuclear factor kappa B [NF kappa B], CD3+, cyclooxygenase 2 [COX-2], toll-like receptor 4 [TLR4], phosphorylated signal transducers and activators of transcription 3 [pSTAT-3], tumor necrosis factor alpha [TNF-alpha], interleukin 6 [IL-6], and IL-1 beta) and oxidative-stress (catalase, superoxide dismutase 2 [SOD2], glutathione reductase [GSR], reduced glutathione, and glutathione peroxidase 3 [GPx3]) related molecules were analyzed by western-blotting, immunohistochemistry, and enzyme-linked immunosorbent assays. PJE exerted a dose-dependent effect controlling inflammation and oxidative-stress in aging and HFD-fed aging mice prostate. This fact contributed to prostate microenvironment balance recovery, preserving the tissue architecture of this gland. Thus, the PJE emerges as a potential therapy to prevent inflammation and oxidative stress in the prostate
Subject: Compostos bioativos
Obesidade
Country: Estados Unidos
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1002/pros.24017
Address: https://onlinelibrary.wiley.com/doi/full/10.1002/pros.24017
Date Issue: 2020
Appears in Collections:IB - Artigos e Outros Documentos
FEA - Artigos e Outros Documentos

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