Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/350693
Type: Artigo
Title: Preliminary evaluation of antioxidant, antiproliferative and antimutagenic activities of pitomba (talisia esculenta)
Author: Neri-Numa, Iramaia Angélica
Carvalho-Silva, Luciano Bruno de
Ferreira, Jose Emilson Macedo
Machado, Ana Rita Tomazela
Malta, Luciana Gomes
Ruiz, Ana Lucia Tasca Gois
Carvalho, João Ernesto de
Pastore, Glaucia Maria
Abstract: The present study provides preliminary data about the total polyphenols and flavonoids content, antioxidant, antiproliferative, and antimutagenic activities of crude extract of pitomba (Talisia esculenta). Levels of flavonoids aglycons obtained after acid hydrolysis to myricetin and quercetin by HPLC were 89.90 mg/100 g and 30.20 mg/100 g, respectively. Total polyphenols and flavonoid contents found were 105.84 ± 2 .05 mg GAE/g and 88.05 ± 0.04 mg CE/g for the extract, respectively. Average values for the DPPHIC50, TEAC using ABTS and T-ORAC assays were 9.56 ± 6.75 μg/mL, 115.69 ± 4.23 TE μg/g and 1692.96 μmol TE/100 g, respectively. Regarding the ability to inhibit the growth of tumor cell lines, we observed an antiproliferative activity against UACC-62 (2.6 μg/mL), NCI-ADR/RES (3.1 μg/mL), and OVCAR-3 (3.1 μg/mL) cell lines. By micronucleus test, our extract showed anticlastogenic activity at all concentration level tested. These results suggest that T. esculenta extract has great antioxidant potential that could be used as a preventive agent for cancer. However, additional studies are needed to evaluate the mechanism of action of these compounds as well as the adverse effects in other bioassay systems and animal models
Subject: Antioxidantes
Flavonóides
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.lwt.2014.06.034
Address: https://www.sciencedirect.com/science/article/pii/S0023643814003879
Date Issue: 2014
Appears in Collections:FEA - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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