Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/350628
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMoreira, Débora Kono Taketa-
dc.contributor.authorunicampMorais, Thainá Rodrigues de-
dc.contributor.authorunicampGandra, Renata Luana de Pádua-
dc.contributor.authorunicampZuin, Julia Cristina-
dc.contributor.authorunicampMacedo, Juliana Alves-
dc.contributor.authorunicampMacedo, Gabriela Alves-
dc.contributor.authorunicampGambero, Alessandra-
dc.typeArtigopt_BR
dc.titleStructured lipid containing behenic acid versus orlistat for weight loss: an experimental study in micept_BR
dc.contributor.authorSilva, Reginaldo Marques da-
dc.contributor.authorZarricueta, Melina Luzzi-
dc.contributor.authorMoreira, Débora Kono Taketa-
dc.contributor.authorMorais, Thaina Rodrigues de-
dc.contributor.authorRizzardi, Karina Ferreira-
dc.contributor.authorParisotto, Thais Manzano-
dc.contributor.authorGandra, Renata Luana de Pádua-
dc.contributor.authorZuin, Julia Cristina-
dc.contributor.authorCaria, Cintia Rabelo e Paiva-
dc.contributor.authorMacedo, Juliana Alves-
dc.contributor.authorMacedo, Gabriela Alves-
dc.contributor.authorGambero, Alessandra-
dc.subjectOrlistatept_BR
dc.subject.otherlanguageOrlistatpt_BR
dc.description.abstractExploring dietary alternatives that can help obese patients lose weight and improve metabolic health, we developed a structured lipid rich in behenic acid (SLBeh). The SLBeh was obtained by enzymatic interesterification in a mixture of soy oil, olive oil and fully hydrogenated crambe oil resulting in a final product with good technological characteristics, and with the ability to prevent weight gain and the postprandial inflammation in mice. In this study, we compared the ability of the SLBeh to that of orlistat to induce weight loss in obese mice. Methods Obese mice were fed on a high-fat diet formulated with 50% or 100% SLBeh or treated with orlistat. Body composition, glucose and lipid homeostasis, non-alcoholic fatty liver disease (NAFLD) markers, and feces analysis were assessed. In addition, anin vitro lipase inhibition characterization was performed. Results The SLBeh inhibits lipase partially in comparison with that by orlistat. Diet with the SLBeh was not able to induce weight loss. However, mice had improvements in glucose blood level control; reductions in NAFLD markers; low levels of serum endotoxin; and alterations in microbiota composition. Conclusions Despite the partial inhibition of lipase, the SLBeh could be an interesting lipid alternative in the search for healthier foodpt_BR
dc.relation.ispartofPharmaNutritionpt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2020-
dc.date.monthofcirculationDec.pt_BR
dc.language.isoengpt_BR
dc.description.volume14pt_BR
dc.rightsFechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn2542-520Xpt_BR
dc.identifier.eissn2213-4344pt_BR
dc.identifier.doi10.1016/j.phanu.2020.100213pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2213434420300384pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumber2017/00457-1pt_BR
dc.date.available2020-10-07T12:06:59Z-
dc.date.accessioned2020-10-07T12:06:59Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2020-10-07T12:06:59Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-10-07T12:06:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/350628-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Alimentos e Nutriçãopt_BR
dc.contributor.departmentDepartamento de Ciência de Alimentospt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordWeight losspt_BR
dc.subject.keywordVery long chain saturated fatty acidpt_BR
dc.subject.keywordBehenic acidpt_BR
dc.subject.keywordOrlistpt_BR
dc.subject.keywordAthigh-fat dietpt_BR
dc.subject.keywordPancreatic lipase inhibitorpt_BR
dc.identifier.source2-s2.0-85089416089pt_BR
dc.creator.orcid0000-0002-1405-227Xpt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-8213-1412pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-7504-8111pt_BR
dc.creator.orcid0000-0001-5255-2243pt_BR
dc.creator.orcid0000-0002-4862-4328pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid100213pt_BR
Appears in Collections:FCM - Artigos e Outros Documentos
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