Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/350627
Type: Artigo
Title: Peanut skin polyphenols inhibit toxicity induced by advanced glycation end-products in RAW264.7 macrophages
Author: Fernandes, Annayara Celestina Ferreira
Vieira, Natália Carolina
Santana, Ádina Lima de
Gandra, Renata Luana de Pádua
Rubia, Camila
Castro-Gamboa, Ian
Macedo, Juliana Alves
Macedo, Gabriela Alves
Abstract: This is the first work to use a polyphenolic fraction derived from peanut skin to attenuate the toxicity induced by advanced glycation-end products (AGEs) in RAW264.7 macrophages. The RAW264.7 cells were stimulated by AGEs using the bovine serum albumin-fructose (BSA-FRU), bovine serum albumin-methylglyoxal (BSA-MGO) and arginine-methylglyoxal (ARG-MGO) models. The AGEs increased considerably the levels of reactive oxygen species and the gene expression of proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and nitric oxide. Twenty-eight polyphenols, including catechin, phenolic acids, and resveratrol were annotated in peanut skin extract (PSE) with the use of ultra-performance liquid chromatography coupled to quadrupole time of flight mass spectrometry (UPLC-QTOF/MSE) and to the UNIFI Scientific Information System. The administration of PSE at 100 and 150 μg/mL significantly inhibited oxidative stress, by suppressing the production of reactive oxygen species up to 70% and reducing the production of nitric oxide, IL-6 and TNF-α up to 1.7-, 10- and 107-fold, respectively
Subject: Compostos fenólicos
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.fct.2020.111619
Address: https://www.sciencedirect.com/science/article/pii/S0278691520305093
Date Issue: 2020
Appears in Collections:FEA - Artigos e Outros Documentos

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