Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/350597
Type: Artigo
Title: Enhanced estrogenic effects of biotransformed soy extracts
Author: Ávila, Amanda Rejane Alves de
Queirós, Lívia Dias de
Lopes, Danielle Branta
Barin, Clara Guido
Ueta, Tatiane Mayumi
Ruiz, Ana Lúcia Tasca Gois
Macedo, Gabriela Alves
Macedo, Juliana Alves
Abstract: Soy isoflavones have been associated with several beneficial effects to human health including estrogenic action. Due to the risks associated with pharmaceutical hormone replacement therapy, soy extracts rich in isoflavones and metabolites appear as a safe alternative for menopausal women. This study aimed to improve the process conditions for biotransformation of soymilk polyphenols by tannase to obtain higher amounts of isoflavone aglycones and metabolites such as equol. The estrogenic potential of the extracts was evaluated in in vitro assays. The results showed that the aglycones increased 36–46 times after reaction with tannase and proved that it is possible to produce equol in soymilk using an enzymatic bioprocess, without gut microbial intervention. Moreover, the soymilk biotransformed by tannase presented higher estrogenic action in the MCF-7 BUS cell line assay, making it a promising nutraceutical with possible effects in the attenuation or treatment of menopause symptoms
Subject: Bioatividade
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.jff.2018.06.026
Address: https://www.sciencedirect.com/science/article/pii/S1756464618303220
Date Issue: 2018
Appears in Collections:FEA - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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