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Type: Artigo
Title: Characterization and compatibility study of desloratadine
Author: Trevisan, M. G.
Garcia, J. S.
Daniel, J. S. P.
Veronez, I. P.
Abstract: Desloratadine (DL) is a selective antagonist of the histamine H-1 receptor, which has been widely used to treat allergic symptoms, and stands out from other drugs in this therapeutic class because it does not cause sedative effects. In the present study, the physico-chemical properties of DL were fully characterized using six analytical techniques such as Differential Scanning Calorimetry (DSC), Thermogravimetric analysis (TG/DTG), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, Powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). The DSC curve shows a sharp endothermic event at 158.4 A degrees C, and the TG/DTG curve presents two decomposition events between 178.4 and 451.9 A degrees C. A compatibility study involving DL and nine pharmaceutical excipients generally used in pharmaceutical formulations was performed. Physical binary mixtures of DL with each excipient were prepared in a 1:1 (w/w) ratio. After preparation, the samples were analyzed immediately and the results reveal solid-state interaction with anhydrous lactose, microcrystalline cellulose, magnesium stearate, and stearic acid
Subject: Análise térmica
Country: Hungria
Editor: Springer
Rights: Fechado
Identifier DOI: 10.1007/s10973-013-3271-4
Date Issue: 2014
Appears in Collections:IQ - Artigos e Outros Documentos

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