Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/350283
Type: Artigo
Title: PHEMA-PLLA semi-interpenetrating polymer networks: A study of their swelling kinetics, mechanical properties and cellular behavior
Author: Passos, Marcele Fonseca
Fernandez-Gutierrez, Mar
Vazquez-Lasa, Blanca
San Roman, Julio
Maciel Filho, Rubens
Abstract: Semi-interpenetrating polymer networks (semi-IPNs) have attracted much attention in recent years as biomaterials with a high potential in tissue engineering and controlled drug release. In this article, semi-IPNs were synthetized by free radical polymerization of 2-hydroxyethyl methacrylate (HEMA) in the presence of poly(l-lactic acid) (PLLA) with contents of 5, 10 and 20 wt.% at high temperature (150 °C). The study focused on the analysis of thermal and mechanical properties, wettability, swelling kinetics in buffered solutions of different pH, and biocompatibility using fibroblasts of human embryonic skin. Segregation of the components in different microdomains was verified by morphological analysis through scanning electron microscopy (SEM). Differential scanning calorimetry (DSC) results revealed that the poly(2-hydroxyethyl methacrylate) (PHEMA) network is amorphous and the PLLA is semi-crystalline. Mechanical analysis provided Young’s modulus values in the range 240–370 MPa in tensile tests, and storage modulus (E′) values at 37 °C, 1 Hz, in the range 800–1200 MPa. Equilibrium water uptake measurements displayed material dependence on composition and pH. Swelling kinetics presented good agreement with a second-order diffusion process in all media. No sample present cytotoxicity and the cell migration process occupied many semi-IPNs pores closing them and indicating good cellular recognition. In overall, these networks can be considered for their application as scaffolds for bone defects augmentation and subchondral cartilage repair
Subject: PLLA
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.eurpolymj.2016.10.023
Address: https://www.sciencedirect.com/science/article/pii/S0014305716308874
Date Issue: 2016
Appears in Collections:FEQ - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000390497100014.pdf11.29 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.