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Type: Artigo
Title: Viability assays of PLLA fibrous membranes produced by rotary jet spinning for application in tissue engineering
Author: Ciocca, Barbara Etruri
Jardini Munhoz, Andre Luiz
Camargo Cardoso, Guinea Brasil
Rodigues, Ana Amelia
Pattaro, Ana Flavia
Kaasi, Andreas
Maciel Filhol, Rubens
Abstract: Tissue engineering suggests different forms to reconstruct tissues and organs. One of the ways is through the use of polymeric biomaterials such as poly(L-lactic acid) (PLLA). PLLA is a recognized material in tissue engineering due to its characteristics as biocompatibility and bioresorbability. In this work PLLA fibrous membranes were produced by a simple technique known as rotary jet spinning. The rotary jet spinning consists of fibrous membranes production, with fibers of scale nano/micrometric, from a polymeric solution through the centrifugal force generated by the equipment. The membranes formed were subjected to preliminary in vitro assays to verify the cytotoxicity of the membranes made in contact with the cells. Direct cytotoxicity assays were performed through the MTT, AlamarBlue® and Live/Dead® tests, with fibroblastic and osteoblastic cells. The results obtained in this study showed that PLLA membranes produced by rotary jet spinning showed promising results in the 24-hours contact period of the cells with the PLLA fibrous membranes. The information presented in this preliminary study provides criteria to be taken in the future procedures that will be performed with the biomaterial produced, aiming at its improvement
Subject: PLLA
Country: Brasil
Editor: Instituto de Tecnologia do Paraná
Rights: Aberto
Identifier DOI: 10.1590/1678-4324-2019170775
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos
FEQ - Artigos e Outros Documentos

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