Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/350022
Type: Artigo
Title: β-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method
Author: Oliveira, Davi Rocha Bernardes
Michelon, Mariano
Furtado, Guilherme de Figueiredo
Sinigaglia-Coimbra, Rita
Cunha, Rosiane Lopes
Abstract: Tristearin solid lipid nanoparticles and tristearin/high oleic sunflower oil nanostructured lipid carriers were produced by solvent displacement method. All conditions allowed forming polydisperse particles within nanometric range and the presence of high oleic sunflower oil did not affect the particles mean size. Nevertheless, incorporation of β-carotene reduced the particles polydispersity. Thermograms of solid lipid nanoparticles and nanostructured lipid carriers showed that sunflower oil generated a crystal order disturbance, since nanoparticles with less-organized lipid matrix were produced. Nanostructured lipid carriers exhibited an improvement of β-carotene loading capacity when compared with solid lipid nanoparticles, which enhanced with the increasing of high oleic sunflower oil content. Although total β-carotene degradation was similar for all systems, color analysis showed that the degradation of encapsulated β-carotene was lower for high sunflower oil content. Nanostructured lipid carriers exhibited advantages over the solid lipid nanoparticles, such as enhanced drug loading capacity and prevention of drug expulsion, which makes this a versatile delivery system for food applications.
Subject: Carotenóides
Lipídeos
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.foodres.2016.10.038
Address: https://www.sciencedirect.com/science/article/pii/S096399691630477X
Date Issue: 2016
Appears in Collections:FEA - Artigos e Outros Documentos

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