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|Title:||Peri-Infarct zone characterized by cardiac magnetic resonance imaging is directly associated with the Inflammatory activity during acute phase myocardial infarction|
|Author:||Silva, J. C. Q. E.|
Coelho, O. R.
Andrade, J. M.
Modolo, R. G. P.
van der Geest, R. J.
Almeida, B. O.
Sposito, A. C.
Coelho, O. R.
|Abstract:||Enhanced systemic inflammatory activity (SIA) during myocardial infarction (MI) and the extent of the peri-infarct zone characterized by cardiac magnetic resonance imaging (CMRi) are both associated with increased risk of life-threatening arrhythmias and sudden cardiac death. The present study investigated the existence of association between these two phenomena in 98 patients (55 +/- 10 years) with ST segment elevation MI. Plasma levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor (TNF) were measured on admission (D1) and on the fifth day post-MI (D5). CMRi was performed 2 weeks after MI to quantify peri-infarct zone (PIZ). Between D1 and D5, the increase in CRP (6.0 vs. 5.6 times; p = 0.02), IL-2 (3.6 vs. 3.4 times; p = 0.04) and tumor necrosis factor type alpha (TNF-alpha; 4.6 vs. 3.9 times; p = 0.001) were higher in patients with PIZ above the median than in the counterparts. PIZ was correlated with CRP-D5 (r = 0.69), delta-CRP (r = 0.7), IL-2-D5 (r = 0.5), delta-IL-2 (r = 0.6), TNF-alpha (r = 0.5), delta-TNF-alpha (r = 0.4; p = 0.0001). Enhanced activation of SIA during the acute phase of MI is directly related with generation of PIZ|
|Subject:||Imagem de ressonância magnética|
Infarto do miocárdio
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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