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Type: Artigo
Title: Jaboticaba peel extract decrease autophagy in white adipose tissue and prevents metabolic disorders in mice fed with a high-fat diet
Author: Baseggio, Andressa Mara
Nuñez, Carla Evelyn Coimbra
Dragano, Nathalia Romanelli Vicente
Lamas, Celina Almeida
Braga, Patrícia Aparecida de Campos
Lenquiste, Sabrina Alves
Reyes, Felix Guillermo Reyes
Cagnon, Valéria Helena Alves
Maróstica Júnior, Mário Roberto
Abstract: The increase in autophagy markers in the white adipose tissue is associated with adipocyte hypertrophy and obesity physiopathology. The jaboticaba peel is rich in bioactive compounds as polyphenols, which have been demonstrating anti-oxidant and inflammatory effects, and possibly interferes in adipose tissue metabolism and obesity. Thus, this study aimed to evaluate the effects of jaboticaba peel extract (FJE) treatment in autophagy markers of epididymal and inguinal white adipose tissue (eWAT and iWAT) of mice fed a normocaloric or high-fat diet for 6 weeks. The FJE treatment modulates autophagy markers in the eWAT of animals fed a high-fat diet by the reduction of Beclin-1 and LC3BII, and an increase in SQSTM-p62, accompanied by a decrease in tissue and total body weight, indicating the importance of autophagy in obesity development. These alterations were not followed by lower cytokines concentration, suggesting that autophagy may be fundamental to adipocyte remodeling at the beginning of adipocyte hypertrophy, before the onset of low-grade inflammation. Furthermore, the treatment reduced total serum triglycerides and liver fat accumulation. Thus, the results suggest that FJE could be considered a strategy against metabolic disorders caused by an HF diet
Subject: Autofagia
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.phanu.2018.06.006
Date Issue: 2018
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos
FEA - Artigos e Outros Documentos

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