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Type: Artigo
Title: Antibacterial compounds from marine bacteria, 2010–2015
Author: Schinke, Claudia
Martins, Thamires
Queiroz, Sonia C. N.
Melo, Itamar S.
Reyes, Felix G. R.
Abstract: This review summarizes the reports on antibacterial compounds that have been obtained from marine-derived bacteria during the period 2010–2015. Over 50 active compounds were isolated during this period, most of which (69%) were obtained from Actinobacteria. Several compounds were already known, such as etamycin A (11) and nosiheptide (65), and new experiments with them showed some previously undetected antibacterial activities, highlighting the fact that known natural products may be an important source of new antibacterial leads. New broad-spectrum antibacterial compounds were reported with activity against antibiotic resistant Gram-positive and Gram-negative bacteria. Anthracimycin (33), kocurin (66), gageotetrins A–C (72–74), and gageomacrolactins 1–3 (86–88) are examples of compounds that display promising properties and could be leads to new antibiotics. A number of microbes produced mixtures of metabolites sharing similar chemical scaffolds, and structure–activity relationships are discussed
Subject: Agentes antibacterianos
Country: Estados Unidos
Editor: American Chemical Society
Rights: Fechado
Identifier DOI: 10.1021/acs.jnatprod.6b00235
Date Issue: 2017
Appears in Collections:FEA - Artigos e Outros Documentos

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