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Type: Artigo
Title: Ulcerative colitis: gut microbiota, immunopathogenesis and application of natural products in animal models
Author: Nascimento, Roberto de Paula do
Machado, Ana Paula da Fonseca
Galvez, Julio
Cazarin, Cinthia Baú Betim
Maróstica Junior, Mario Roberto
Abstract: Ulcerative colitis (UC) is an inflammatory bowel disease with increasing incidence in the world, especially in developing countries. Although knowledge of its pathogenesis has progressed over the last years, some details require clarification. Studies have highlighted the role of microbial dysbiosis and immune dysfunction as essential factors that may initiate the typical high-grade inflammatory outcome. In order to better understand the immunopathophysiological aspects of UC, experimental murine models are valuable tools. Some of the most commonly used chemicals to induce colitis are trinitrobenzene sulfonic acid, oxazolone and dextran sodium sulfate. These may also be used to investigate new ways of preventing or treating UC and therefore improving targeting in human studies. The use of functional foods or bioactive compounds from plants may constitute an innovative direction towards the future of alternative medicine. Considering the above, this review focused on updated information regarding the 1. gut microbiota and immunopathogenesis of UC; 2. the most utilized animal models of the disease and their relevance; and 3. experimental application of natural products, not yet tested in clinical trials
Subject: Compostos bioativos
Country: Estados Unidos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.lfs.2020.118129
Date Issue: 2020
Appears in Collections:FEA - Artigos e Outros Documentos

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