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Type: Artigo
Title: Intestinal anti-inflammatory effects of passiflora edulis peel in the dextran sodium sulphate model of mouse colitis
Author: Cazarin, Cinthia Baú Betim
Rodriguez-Nogales, Alba
Algieri, Francesca
Utrilla, M. Pilar
Rodríguez-Cabezas, M. Elena
Garrido-Mesa, José
Guerra-Hernández, Eduardo
Braga, Patrícia Aparecida de Campos
Reyes, Felix Guillermo Reyes
Maróstica Jr, Mário Roberto
Gálvez, Julio
Abstract: Low dietary fibre intake has been associated with inflammatory bowel disease incidence. Passiflora edulis peel is considered to be a functional food because of its level of dietary fibre and polyphenols. Female C57BL/6J mice were assigned to three different groups: healthy, dextran sodium sulphate (DSS)-control, and Passiflora edulis treated. Treatment with P. edulis peel flour (8 mg/mL in the drinking water) started 2 weeks before colitis induction, which was performed by adding DSS in the drinking water (3%) for 5 days. P. edulis peel intake exerted an intestinal anti-inflammatory effect and attenuated the colonic damage caused by the DSS, as shown by the reduced disease activity index (DAI) values and after histological evaluation. Biochemical and molecular analyses revealed reduced expression of pro-inflammatory cytokine expression and enhanced intestinal protective barrier. Besides these effects, increases in short-chain fatty acid formation were observed, thus supporting a prebiotic effect
Subject: Maracujá
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.jff.2016.08.020
Date Issue: 2016
Appears in Collections:FEA - Artigos e Outros Documentos

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