Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/349223
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampZanutto, Fabiana Volpe-
dc.contributor.authorunicampSegundo, João de Deus Pereira de Moraes-
dc.contributor.authorunicampSalles, Taís Helena Costa-
dc.contributor.authorunicampServat-Medina, Leila-
dc.contributor.authorunicampSousa, Ilza Maria de Oliveira-
dc.contributor.authorunicampD'Avila, Marcos Akira-
dc.contributor.authorunicampFoglio, Mary Ann-
dc.typeArtigopt_BR
dc.titleDevelopment of membrane by electrospinning containing semi-synthetic derivatives of artemisia annua Linnaeuspt_BR
dc.contributor.authorZanutto, FV-
dc.contributor.authorSegundo, JDPM-
dc.contributor.authorSalles, THC-
dc.contributor.authorServat-Medina, L-
dc.contributor.authorSousa, IM Oliveira-
dc.contributor.authorChorilli, M-
dc.contributor.authord'Ávila, MA-
dc.contributor.authorFoglio, MA-
dc.subjectMalariapt_BR
dc.subject.otherlanguageMalariapt_BR
dc.description.abstractChinese scientists isolated artemisinin from Artemisia annua that provided effective protection against multi-drug resistant strains of P. falciparum. This compound is both insoluble in water and oil, and therefore derivatives with better physicochemical properties were produced by semi-synthesis, including artemether that is currently a first -line drugs for malaria treatment [1,3]. Malaria is among neglected diseases, which kill approximately 300 million people per year worldwide [2,3]. Scientists are continuously in search for new formulations with stability and greater patient's adherence to treatment. Here we report the development of pharmaceutical systems with controlled drug release. Methods: Membrane preparations containing B) 2,5% and C) 5% artemether were produced with 13,6% A) poli(ε-caprolactone) (PCL) solution dissolved in a 1:1 acetone:chloroform mixture by weight and maintained under mechanical agitation for 1 hour. For the electrospinning process, a system comprising of an infusion pump, and a high voltage power source was employed under the experimental conditions: with DC input of 14 kV, flow rate 8mL/h; working distance 17 cm; needle 21Gx1" connected to the positive pole; electrospinning duration: 20 minutes (duplicate for each solution). The fibers were deposited on a metal collector plane, connected to the negative pole, coated with aluminum foil. The fibers' morphology and diameter was analyzed by Scanning Electron Microscope (SEM). The fibers' diameters were measured using ImageJ® software. Results: According to the results, the membranes with PCL/drug containing the active pharmaceutical ingredient presented large area uniformity, mechanical flexibility and strong adhesion to substrates. From SEM analysis (Figure 1), furthermore, as expected, fibers with higher drug concentration presented higher average diameters of 2,28 ± 1,05 µm and 1,10 ± 0,75 µm for 5 and 2,5wt% drug, respectively. Conclusions: This membrane is promising candidate for development of new solid or semi-solid formulations for topical application or transdermal antimalarial product in a single dosept_BR
dc.relation.ispartofPlanta medica: journal of medicinal plant and natural product researchpt_BR
dc.relation.ispartofabbreviationPlanta medpt_BR
dc.publisher.cityStuttgartpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisherGeorg Thieme Verlagpt_BR
dc.date.issued2016-
dc.date.monthofcirculationDec.pt_BR
dc.language.isoengpt_BR
dc.description.volume81pt_BR
dc.description.issuenumber01pt_BR
dc.description.firstpageS1pt_BR
dc.description.lastpageS381pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0032-0943pt_BR
dc.identifier.eissn1439-0221pt_BR
dc.identifier.doi10.1055/s-0036-1597020pt_BR
dc.identifier.urlhttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1597020pt_BR
dc.date.available2020-09-14T17:18:38Z-
dc.date.accessioned2020-09-14T17:18:38Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-09-14T17:18:38Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-09-14T17:18:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/349223-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Engenharia de Materiaispt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Engenharia Mecânicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Mecânicapt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.contributor.unidadeFaculdade de Engenharia Mecânicapt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.subject.keywordElectrospinningpt_BR
dc.subject.keywordArtemetherpt_BR
dc.subject.keywordPoli (ε-caprolactone)pt_BR
dc.identifier.source000411789300843pt_BR
dc.creator.orcid0000-0003-0148-1080pt_BR
dc.creator.orcid0000-0002-9906-798Xpt_BR
dc.creator.orcid0000-0002-9780-8588pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-3956-3199pt_BR
dc.creator.orcid0000-0003-1981-9692pt_BR
dc.creator.orcid0000-0001-7715-4452pt_BR
dc.type.formArtigopt_BR
Appears in Collections:FEM - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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