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Type: Artigo
Title: Violacein extracted from chromobacterium violaceum inhibits plasmodium growth in vitro and in vivo
Author: Lopes, Stefanie C. P.
Blanco, Yara C.
Justo, Giselle Z.
Nogueira, Paulo A.
Rodrigues, Francisco L. S.
Goelnitz, Uta
Wunderlich, Gerhard
Facchini, Gustavo
Brocchi, Marcelo
Duran, Nelson
Costa, Fabio T. M.
Abstract: Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge
Subject: In Vitro
Chromobacterium - Classificação
Country: Estados Unidos
Editor: American Society for Microbiology
Rights: Fechado
Identifier DOI: 10.1128/AAC.00693-08
Date Issue: 2009
Appears in Collections:IB - Artigos e Outros Documentos

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