Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/349004
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAbbehausen, Camilla-
dc.contributor.authorunicampCastro, Juliana Fukuoka-
dc.contributor.authorunicampSpera, Marcelle Bruna de Mendonça-
dc.contributor.authorunicampFormiga, André Luiz Barboza-
dc.contributor.authorunicampCorbi, Pedro Paulo-
dc.typeArtigopt_BR
dc.titleSynthesis, spectroscopic characterization, DFT studies and biological assays of a novel gold(I) complex with 2-mercaptothiazolinept_BR
dc.contributor.authorAbbehausen, C.-
dc.contributor.authorCastro, J.F.-
dc.contributor.authorSpera, M.B.M.-
dc.contributor.authorHeinrich, T.A.-
dc.contributor.authorCosta-Neto, C.M.-
dc.contributor.authorLustri, W.R.-
dc.contributor.authorFormiga, A.L.B.-
dc.contributor.authorCorbi, P.P.-
dc.subjectAtividade antibacterianapt_BR
dc.subjectCitotoxinaspt_BR
dc.subjectEspectroscopia de infravermelhopt_BR
dc.subject.otherlanguageAntibacterial activitypt_BR
dc.subject.otherlanguageCytotoxinspt_BR
dc.subject.otherlanguageInfrared spectroscopypt_BR
dc.description.abstractA new gold(I) complex with 2-mercaptothiazoline (MTZ) with the coordination formula [AuCN(C3H5NS2)] was synthesized and characterized by chemical and spectroscopic measurements, DFT studies and biological assays. Infrared (IR) and 1H, 13C and 15N nuclear magnetic resonance (NMR) spectroscopic measurements indicate coordination of the ligand to gold(I) through the nitrogen atom. Studies based on DFT confirmed nitrogen coordination to gold(I) as a minimum of the potential energy surface with calculations of the hessians showing no imaginary frequencies. Thermal decomposition starts at temperatures near 160°C, leading to the formation of Au0 as the final residue at 1000°C. The gold(I) complex with 2-mercaptothiazoline (Au-MTZ) is soluble in dimethyl sulfoxide (DMSO), and is insoluble in water, methanol, ethanol, acetonitrile and hexane. The antibacterial activities of the Au-MTZ complex were evaluated by an antibiogram assay using the disc diffusion method. The compound showed an effective antibacterial activity against Staphylococcus aureus (Gram-positive) and Escherichia coli and Pseudomonas aeruginosa (Gram-negative) bacterial cells. Biological analysis for evaluation of the cytotoxic effect of the Au-MTZ complex was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented a potent cytotoxic activity, inducing 85% of cell death at a concentration of 2.0 μmol L-1.pt_BR
dc.relation.ispartofPolyhedronpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2011-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume30pt_BR
dc.description.issuenumber13pt_BR
dc.description.firstpage2354pt_BR
dc.description.lastpage2359pt_BR
dc.rightsFechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn0277-5387pt_BR
dc.identifier.doi10.1016/j.poly.2011.06.021pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0277538711003962pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber141617/2010-1pt_BR
dc.description.sponsordocumentnumber2006/55367-2pt_BR
dc.date.available2020-09-10T00:16:23Z-
dc.date.accessioned2020-09-10T00:16:23Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-09-10T00:16:23Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:13:10Z : No. of bitstreams: 1 2-s2.0-79960988598.pdf: 473066 bytes, checksum: 837befa46171f764021ca4162f08a10d (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-10T00:16:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/349004-
dc.contributor.departmentDepartamento de Química Inorgânicapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Química Inorgânicapt_BR
dc.contributor.departmentDepartamento de Química Inorgânicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.subject.keyword2-Mercaptothiazolinept_BR
dc.subject.keywordCytotoxic assayspt_BR
dc.subject.keywordGold(I)Infrared spectroscopypt_BR
dc.subject.keywordNMR spectroscopypt_BR
dc.identifier.source2-s2.0-79960988598pt_BR
dc.creator.orcid0000-0002-8410-2252pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-7841-0489pt_BR
dc.creator.orcid0000-0001-6773-8083pt_BR
dc.creator.orcid0000-0002-7478-0877pt_BR
dc.type.formArtigopt_BR
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