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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampTormena, Cláudio Francisco-
dc.typeArtigopt_BR
dc.titleMonoamine oxidase inhibitory activities of indolylalkaloid toxins from the venom of the colonial spider Parawixia bistriata: functional characterization of PwTX-Ipt_BR
dc.contributor.authorSaidemberg, D.M.-
dc.contributor.authorFerreira, M.A.B.-
dc.contributor.authorTakahashi, T.N.-
dc.contributor.authorGomes, P.C.-
dc.contributor.authorCesar-Tognoli, L.M.M.-
dc.contributor.authorda Silva-Filho, L.C.-
dc.contributor.authorTormena, C.F.-
dc.contributor.authorda Silva, G.V.J.-
dc.contributor.authorPalma, M.S.-
dc.subjectCromatografiapt_BR
dc.subjectMonoamina oxidasept_BR
dc.subjectAranha - Venenopt_BR
dc.subject.otherlanguageChromatographypt_BR
dc.subject.otherlanguageMonoamine oxidasept_BR
dc.subject.otherlanguageSpiders - Venompt_BR
dc.description.abstractColonial spiders evolved a differential prey-capture behaviour in concert with their venom chemistry, which may be a source of novel drugs. Some highly active tetrahydro-β-carboline (THβC) toxins were recently isolated from the venom of the colonial spider Parawixia bistriata; the spiders use these toxins as part of their chemical arsenal to kill and/or paralyze preys. The major THβC compound isolated from this venom was identified as 6-hydroxytrypargine, also known as PwTX-I. Most natural compounds of animal origin occur in low abundance, and the natural abundance of PwTX-I is insufficient for complete functional characterization. Thus, PwTx-I was synthesized using a Pictet-Spengler condensation strategy, and the stereoisomers of the synthetic toxin were separated by chiral chromatography. The fraction of venom containing a mixture of three natural THβC toxins and enantiomers of PwTx-I were analyzed for inhibition of monoamine oxidase (MAO)-A and -B and for toxicity to insects. We reveal that the mixture of the natural THβC toxins, as well as the enantiomers of PwTx-I, were non-competitive inhibitors of MAO-A and MAO-B and caused potent paralysis of honeybees. The (-)-PwTX-I enantiomer is 2-fold more potent than the (+)-PwTX-I enantiomer in the assays performedpt_BR
dc.relation.ispartofToxicon: an interdisciplinary journal on the toxins derived from animals, plants and microorganismspt_BR
dc.relation.ispartofabbreviationToxiconpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2009-
dc.date.monthofcirculationNov.pt_BR
dc.language.isoengpt_BR
dc.description.volume54pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage717pt_BR
dc.description.lastpage724pt_BR
dc.rightsFechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn0041-0101pt_BR
dc.identifier.eissn1879-3150pt_BR
dc.identifier.doi10.1016/j.toxicon.2009.05.027pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0041010109002815pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumber4/07942-2; 06/50158-6; 06/57122-7pt_BR
dc.date.available2020-09-09T23:54:33Z-
dc.date.accessioned2020-09-09T23:54:33Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-09-09T23:54:33Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:13:09Z : No. of bitstreams: 1 2-s2.0-69049097009.pdf: 464500 bytes, checksum: e3c874ddb7ca5c6549490d1c140a8e73 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-09T23:54:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/349000-
dc.contributor.departmentDepartamento de Química Orgânicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.subject.keywordChiral chromatographyIndoylalkaloidpt_BR
dc.subject.keywordParawixiatoxinpt_BR
dc.identifier.source2-s2.0-69049097009pt_BR
dc.creator.orcid0000-0002-1508-0694pt_BR
dc.type.formArtigopt_BR
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