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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCagnon, Valéria Helena Alves-
dc.typeArtigopt_BR
dc.titleIGFR-I expression and structural analysis of the hard palatine mucosa in an ethanol-drinking rat strain (UChA and UChB)pt_BR
dc.contributor.authorMartinez, M.-
dc.contributor.authorDe Oliveira, S. A.-
dc.contributor.authorPinheiro, P. F. F.-
dc.contributor.authorAlmeida-Francia, C.-
dc.contributor.authorPereira, S.-
dc.contributor.authorMartins, O. A.-
dc.contributor.authorMello-Junior, W.-
dc.contributor.authorMendes, L. O.-
dc.contributor.authorChuffa, L. G. A.-
dc.contributor.authorTirapelli, L. F.-
dc.contributor.authorFavaro, W. J.-
dc.contributor.authorCagnon, V. H. A.-
dc.contributor.authorMartinez, F. E.-
dc.subjectPalato duropt_BR
dc.subject.otherlanguagePalate, hardpt_BR
dc.description.abstractThe study analyzed the effects of chronic alcohol ingestion on the ultrastructure of the lining epithelium of the hard palatine mucosa of rats UChA and UChB (lines with voluntary alcohol consumption) in order to contribute to the understanding of the consequences of alcohol abuse for the morphology of the digestive system. Thirty female adult animals aged 120 days were divided into three experimental groups. (1) Ten UChA rats (genetically low ethanol consumer) with voluntary intake of 10% v/v (5.45 g/kg/day) ethanol solution and water. (2) Ten UChB (genetically high ethanol consumer) rats with voluntary intake of 10% v/v (7.16 g/kg/day) ethanol solution and water. (3) Ten Wistar rats with voluntary ad libitum water intake (control group). Both groups received Nuvital pellets ad libitum. The IGFR-I expression was intense in both experimental groups. The epithelial cells of the alcoholic rats UChA and UChB showed many alterations such as the presence of lipid droplets, altered nuclei, nuclei in corneum layer and disrupted mitochondria. It was concluded that ethanol intake induces ultrastructural lesions in the hard palatine mucosapt_BR
dc.relation.ispartofTissue and cellpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2011-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume43pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage101pt_BR
dc.description.lastpage107pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0040-8166pt_BR
dc.identifier.doi10.1016/j.tice.2010.12.005pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0040816611000036pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2020-09-09T21:23:05Z-
dc.date.accessioned2020-09-09T21:23:05Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-09-09T21:23:05Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:13:09Z : No. of bitstreams: 1 000289333200005.pdf: 2281576 bytes, checksum: a1124ca8012055eece3a93ff6845e4a0 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-09T21:23:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348991-
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordMucosapt_BR
dc.subject.keywordAlcoholismpt_BR
dc.subject.keywordIGFR-Ipt_BR
dc.subject.keywordUChA and UChB ratspt_BR
dc.identifier.source000289333200005pt_BR
dc.creator.orcid0000-0001-5331-7376pt_BR
dc.type.formArtigopt_BR
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