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Type: Artigo
Title: Expression of matrix metalloproteinases-2 and-9 and RECK during alveolar bone regeneration in rat
Author: Accorsi-Mendonca, Thais
da Silva Paiva, Katiucia Batista
Zambuzzi, Willian Fernando
Cestari, Tania Mary
Lara, Vanessa Soares
Sogayar, Mari Cleide
Taga, Rumio
Granjeiro, Jose Mauro
Abstract: MMPs are endopeptidases that play a pivotal role in ECM turnover. RECK is a single membrane-anchored MMP-regulator. Here, we evaluated the temporal and spatial expression of MMP-2, MMP-9, and RECK during alveolar bone regeneration. The maxillary central incisor of Wistar rats was extracted and the animals were killed at 1, 3, 7, 10, 14, 21, 28, and 42 days post-operatively (n = 3/period). The hemimaxillae were collected, demineralized and embedded in paraffin. Immunohistochemical analysis was performed by the immunoperoxidase technique with polyclonal antibodies. On day 1, polymorphonuclear cells in the blood clot presented mild immunolabeling for MMPs. During bone remodeling, osteoblasts facing new bone showed positive staining for gelatinases and RECK in all experimental periods. MMPs were also found in the connective tissue and endothelial cells. Our results show for the first time that inactive and/or active forms of MMP-2, MMP-9 and RECK are differentially expressed by osteogenic and connective cells during several events of alveolar bone regeneration. This may be important for the replacement of the blood clot by connective tissue, and in the formation, maturation and remodeling of new bone
Subject: Metaloproteinases da matriz
Ossos - Regeneração
Country: Países Baixos
Editor: Springer
Rights: Fechado
Identifier DOI: 10.1007/s10735-007-9152-z
Date Issue: 2008
Appears in Collections:IB - Artigos e Outros Documentos

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