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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFerrari, Elenice Aparecida de Moraes-
dc.typeArtigopt_BR
dc.titleGlutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsypt_BR
dc.contributor.authorMelo, L. L.-
dc.contributor.authorSantos, P.-
dc.contributor.authorMedeiros, P.-
dc.contributor.authorMello, R. O.-
dc.contributor.authorFerrari, E. A. M.-
dc.contributor.authorBrandao, M. L.-
dc.contributor.authorMaisonnette, S. S.-
dc.contributor.authorFrancisco, A.-
dc.contributor.authorCoimbra, N. C.-
dc.subjectHaloperidolpt_BR
dc.subject.otherlanguageHaloperidolpt_BR
dc.description.abstractThe inferior colliculus (IC) is primarily involved in the processing of auditory information, but it is distinguished from other auditory nuclei in the brainstem by its connections with structures of the motor system. Functional evidence relating the IC to motor behavior derives from experiments showing that activation of the IC by electrical stimulation or excitatory amino acid microinjection causes freezing, escape-like behavior, and immobility. However, the nature of this immobility is still unclear. The present study examined the influence of excitatory amino acid-mediated mechanisms in the IC on the catalepsy induced by the dopamine receptor blocker haloperidol administered systemically (1 or 0.5 mg/kg) in rats. Haloperidol-induced catalepsy was challenged with prior intracollicular microinjections of glutamate NMDA receptor antagonists, MK-801 (15 or 30 mmol/0.5 mu l) and AP7 (10 or 20 nmol/0.5 mu l), or of the NMDA receptor agonist N-methyl-D-aspartate (NMDA, 20 or 30 nmol/0.5 mu l). The results showed that intracollicular microinjection of MK-801 and AP7 previous to systemic injections of haloperidol significantly attenuated the catalepsy, as indicated by a reduced latency to step down from a horizontal bar. Accordingly, intracollicular microinjection of NMDA increased the latency to step down the bar. These findings suggest that glutamate-mediated mechanisms in the neural circuits at the IC level influence haloperidol-induced catalepsy and participate in the regulation of motor activitypt_BR
dc.relation.ispartofBrain researchpt_BR
dc.relation.ispartofabbreviationBrain res.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2010-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume1349pt_BR
dc.description.firstpage41pt_BR
dc.description.lastpage47pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0006-8993pt_BR
dc.identifier.eissn1872-6240pt_BR
dc.identifier.doi10.1016/j.brainres.2010.06.020pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0006899310013557pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber470119/2004-7; 300227/2004-3pt_BR
dc.description.sponsordocumentnumber2007/0174-1pt_BR
dc.date.available2020-09-09T15:52:41Z-
dc.date.accessioned2020-09-09T15:52:41Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-09-09T15:52:41Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:13:05Z : No. of bitstreams: 1 000281300300005.pdf: 743493 bytes, checksum: 15a5df8f6d7aae2f241013280464e387 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-09T15:52:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348954-
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordInferior colliculuspt_BR
dc.subject.keywordCatalepsypt_BR
dc.subject.keywordGlutamatept_BR
dc.subject.keywordNMDApt_BR
dc.identifier.source000281300300005pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigo de pesquisapt_BR
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