Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348944
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampTata, Alessandra-
dc.contributor.authorunicampFernandes, Anna Maria Alves de Piloto-
dc.contributor.authorunicampSantos, Vanessa Gonçalves dos-
dc.contributor.authorunicampAlberici, Rosana Maria-
dc.contributor.authorunicampAraldi, Dionéia-
dc.contributor.authorunicampParada, Carlos Amílcar-
dc.contributor.authorunicampEberlin, Marcos Nogueira-
dc.typeArtigopt_BR
dc.titleNanoassisted laser desorption-ionization-ms imaging of tumorspt_BR
dc.contributor.authorTata, Alessandra-
dc.contributor.authorFernandes, Anna Maria A. P.-
dc.contributor.authorSantos, Vanessa G.-
dc.contributor.authorAlberici, Rosana M.-
dc.contributor.authorAraldi, Dioneia-
dc.contributor.authorParada, Carlos A.-
dc.contributor.authorBraguini, Wellington-
dc.contributor.authorVeronez, Luciana-
dc.contributor.authorBisson, Gabriela Silva-
dc.contributor.authorReis, Felippe H. Z.-
dc.contributor.authorAlberici, Luciane C.-
dc.contributor.authorEberlin, Marcos N.-
dc.subjectIonizaçãopt_BR
dc.subjectTumorespt_BR
dc.subject.otherlanguageIonizationpt_BR
dc.subject.otherlanguageTumorspt_BR
dc.description.abstractThe ability of nanoassisted laser desorption-ionization mass spectrometry (NALDI-MS) imaging to provide selective chemical monitoring with proper spatial distribution of lipid profiles from tumor tissues after plate imprinting has been tested. NALDI-MS imaging identified and mapped several potential lipid biomarkers in a murine model of melanoma tumor (inoculation of B16/F10 cells). It also confirmed that the in vivo treatment of tumor bearing mice with synthetic supplement containing phosphoethanolamine (PHO-S) promoted an accentuated decrease in relative abundance of the tumor biomarkers. NALDI-MS imaging is a matrix-free LDI protocol based on the selective imprinting of lipids in the NALDI plate followed by the removal of the tissue. It therefore provides good quality and selective chemical images with preservation of spatial distribution and less interference from tissue material. The test case described herein illustrates the potential of chemically selective NALDI-MS imaging for biomarker discoverypt_BR
dc.relation.ispartofAnalytical chemistrypt_BR
dc.relation.ispartofabbreviationAnal. chem.pt_BR
dc.publisher.cityWashington, DCpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherAmerican Chemical Societypt_BR
dc.date.issued2012-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume84pt_BR
dc.description.issuenumber15pt_BR
dc.description.firstpage6341pt_BR
dc.description.lastpage6345pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0003-2700pt_BR
dc.identifier.eissn1520-6882pt_BR
dc.identifier.doi10.1021/ac301202qpt_BR
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/ac301202qpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.date.available2020-09-09T15:10:15Z-
dc.date.accessioned2020-09-09T15:10:15Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-09-09T15:10:15Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:13:04Z : No. of bitstreams: 1 000307159200014.pdf: 3415251 bytes, checksum: 43ec1d5aa3406ffebb23a49af10038fb (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-09T15:10:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348944-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.departmentDepartamento de Química Orgânicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordNanoassistedpt_BR
dc.identifier.source000307159200014pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-5209-8853pt_BR
dc.creator.orcid0000-0003-4868-0618pt_BR
dc.type.formArtigopt_BR
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