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Type: Artigo
Title: Leishmanicidal activity of fractions rich in aporphine alkaloids from amazonian unonopsis species
Author: Silva, Felipe M. A. da
Koolen, Hector H. F.
Lima, Janaína P. S. de
Santos, Delvânia M. F.
Jardim, Izaltina Silva
Souza, Afonso D. L. de
Pinheiro, Maria Lúcia Belém
Abstract: In vitro evaluation of alkaloidal fractions of twigs, barks and leaves from two Unonopsis species, Unonopsis guatterioides R.E. Fr. and Unonopsis duckei R.E. Fr., Annonaceae, against promastigote forms of Leishmania amazonensis revealed these species as sources of substances with promising leishmanicidal potential. All alkaloidal fractions from twigs, barks and leaves of U. guatterioides were classified as highly active, with IC50 1.07, 1.90, and 2.79 mg/mL, respectively. Only the alkaloidal fraction from the twigs of U. duckei was classified as inactive
Subject: Alcaloides
Country: Brasil
Editor: Springer
Rights: Aberto
Identifier DOI: 10.1590/S0102-695X2012005000103
Date Issue: 2012
Appears in Collections:IQ - Artigos e Outros Documentos

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