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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGiorgio, Selma-
dc.typeArtigopt_BR
dc.titleHypoxia modulates phenotype, inflammatory response, and leishmanial infection of human dendritic cellspt_BR
dc.contributor.authorBosseto, Maira Cegatti-
dc.contributor.authorBonini Palma, Patricia Vianna-
dc.contributor.authorCovas, Dimas Tadeu-
dc.contributor.authorGiorgio, Selma-
dc.subjectCélulas dendríticaspt_BR
dc.subjectLeishmaniosept_BR
dc.subjectHipóxiapt_BR
dc.subject.otherlanguageDendritic cellspt_BR
dc.subject.otherlanguageLeishmaniasispt_BR
dc.subject.otherlanguageHypoxiapt_BR
dc.description.abstractDevelopment of hypoxic areas occurs during infectious and inflammatory processes and dendritic cells (DCs) are involved in both innate and adaptive immunity in diseased tissues. Our group previously reported that macrophages exposed to hypoxia were infected with the intracellular parasite Leishmania amazonensis, but showed reduced susceptibility to the parasite. This study shows that although hypoxia did not alter human DC viability, it significantly altered phenotypic and functional characteristics. The expression of CD1a, CD80, and CD86 was significantly reduced in DCs exposed to hypoxia, whereas CD11c, CD14, CD123, CD49 and HLA-DR expression remained unaltered in DCs cultured in hypoxia or normoxia. DC secretion of IL-12p70, the bioactive interleukin-12 (IL-12), a cytokine produced in response to inflammatory mediators, was enhanced under hypoxia. In addition, phagocytic activity (Leishmania uptake) was not impaired under hypoxia, although this microenviroment induced infected DCs to reduce parasite survival, consequently controlling the infection rate. All these data support the notion that a hypoxic microenvironment promotes selective pressure on DCs to assume a phenotype characterized by pro-inflammatory and microbial activities in injured or inflamed tissues and contribute to the innate immune responsept_BR
dc.relation.ispartofActa pathologica, microbiologica et immunologica scandinavicapt_BR
dc.relation.ispartofabbreviationAPMISpt_BR
dc.publisher.cityHoboken, NJpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherJohn Wiley & Sonspt_BR
dc.date.issued2010-
dc.date.monthofcirculationFeb.pt_BR
dc.language.isoengpt_BR
dc.description.volume118pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage108pt_BR
dc.description.lastpage114pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0903-4641pt_BR
dc.identifier.eissn1600-0463pt_BR
dc.identifier.doi10.1111/j.1600-0463.2009.02568.xpt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-0463.2009.02568.xpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.date.available2020-09-09T13:56:38Z-
dc.date.accessioned2020-09-09T13:56:38Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-09-09T13:56:38Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:13:02Z : No. of bitstreams: 1 000273883500004.pdf: 227794 bytes, checksum: 69cf051731f5f29997863463de137230 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-09T13:56:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348929-
dc.contributor.departmentDepartamento Biologia Animalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordInterleukin-12pt_BR
dc.identifier.source000273883500004pt_BR
dc.creator.orcid0000-0002-5685-9661pt_BR
dc.type.formArtigopt_BR
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