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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBerni Neto, Elias Antonio-
dc.typeArtigopt_BR
dc.titleEvaluation of candida albicans adhesion and biofilm formation on a denture base acrylic resin containing silver nanoparticlespt_BR
dc.contributor.authorWady, A. F.-
dc.contributor.authorMachado, A. L.-
dc.contributor.authorZucolotto, V.-
dc.contributor.authorZamperini, C. A.-
dc.contributor.authorBerni, E.-
dc.contributor.authorVergani, C. E.-
dc.subjectBiofilmespt_BR
dc.subject.otherlanguageBiofilmspt_BR
dc.description.abstractThis study firstly evaluated the activity of a silver nanoparticle (AgNPs) solution against Candida albicans and then the effect of incorporation of AgNPs into a denture base acrylic resin on the material’s hydrophobicity, C. albicans adhesion and biofilm formation. Methods and Results: The AgNPs solution was synthesized by chemical reduction and characterized. Minimum inhibitory (MIC) and minimum fungicidal (MFC) concentrations for planktonic cells and sessile cells (MFCs) of the AgNPs solution against C. albicans were determined. Specimens (n = 360) of silver‐incorporated acrylic resin at concentrations of 1000, 750, 500, 250 and 30 ppm were also prepared and stored in PBS for 0, 7, 90 and 180 days. Control was acrylic resin without AgNPs (0 ppm). After the storage periods, contact angles were measured and the specimens were used for C. albicans adherence (37°C; 90 min; n = 9) and biofilm formation (37°C; 48 h; n = 9) by XTT reduction assay. MIC, MFC and MFCs values were 3·98, 15·63 and 1000 ppm, respectively. Incorporation of AgNPs reduced the hydrophobicity of the resin. No effect on adherence and biofilm formation was observed. At 90 and 180 days of storage, there was significant increase in adherence and biofilm formation. Conclusions: Although the AgNPs solution had antifungal activity, no effect on C. albicans adherence and biofilm formation was observed after its incorporation into a denture base resin. Significance and Impact of the Study: The synthesized AgNPs solution is a promising antifungal agent, warranting investigations of more efficient methods of incorporation into denture base resinspt_BR
dc.relation.ispartofJournal of applied microbiologypt_BR
dc.relation.ispartofabbreviationJ appl microbiolpt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2012-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume112pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage1163pt_BR
dc.description.lastpage1172pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1364-5072pt_BR
dc.identifier.eissn1365-2672pt_BR
dc.identifier.doi10.1111/j.1365-2672.2012.05293.xpt_BR
dc.identifier.urlhttps://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2672.2012.05293.xpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2008/11700-5; 2008/07454-9pt_BR
dc.date.available2020-09-09T13:40:37Z-
dc.date.accessioned2020-09-09T13:40:37Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2020-09-09T13:40:37Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:13:02Z : No. of bitstreams: 1 000303854700011.pdf: 1052541 bytes, checksum: 348d8fe737a9fd050ea9726e25e50935 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-09T13:40:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348924-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.subject.keywordCandida albicanspt_BR
dc.subject.keywordDenturespt_BR
dc.subject.keywordNanoparticlespt_BR
dc.subject.keywordStomatitispt_BR
dc.identifier.source000303854700011pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigo originalpt_BR
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