Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348906
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampRidolfi, Daniela Missiani-
dc.contributor.authorunicampGaspari, Priscyla Daniely Marcato-
dc.contributor.authorunicampJusto, Giselle Zenker-
dc.contributor.authorunicampCordi, Livia-
dc.contributor.authorunicampMachado, Daisy-
dc.contributor.authorunicampDuran Caballero, Nelson Eduardo-
dc.typeArtigopt_BR
dc.titleChitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoinpt_BR
dc.contributor.authorRidolfi, Daniela M.-
dc.contributor.authorMarcato, Priscyla D.-
dc.contributor.authorJusto, Giselle Z.-
dc.contributor.authorCordi, Lívia-
dc.contributor.authorMachado, Daisy-
dc.contributor.authorDurán, Nelson-
dc.subjectQuitosanapt_BR
dc.subject.otherlanguageChitosanpt_BR
dc.description.abstractTretinoin (TRE) or all-trans retinoic acid is employed in the topical treatment of various skin diseases including acne and psoriasis. However, its use is strongly limited by side effects and high chemical instability. TRE encapsulation in nanostructured systems reduces these problems. Chitosan is a biopolymer that exhibits a number of interesting properties such as bioadhesion and antibacterial activity. The aim of this work was to prepare and characterize solid lipid nanoparticles (SLN) containing TRE, with and without addition of chitosan, to assess their in vitro cytotoxicity in keratinocytes and to evaluate their antibacterial activity against bacteria related to acne. SLN without (SLN-TRE) and with (SLN-chitosan-TRE) chitosan were prepared by hot high pressure homogenization. The hydrodynamic mean diameter and zeta potential were 162.7 ± 1.4 nm and −31.9 ± 2.0 mV for SLN-TRE, and 284.8 ± 15.0 nm and 55.9 ± 3.1 mV for SLN-chitosan-TRE. The SLN-chitosan-TRE exhibited high encapsulation efficiency, high physical stability in the tested period (one year), were not cytotoxic to keratinocytes and showed high antibacterial activity against P. acnes and S. aureus. Therefore chitosan-SLN can be good candidates to encapsulate TRE and to increase its therapeutic efficacy in the topical treatment of acnept_BR
dc.relation.ispartofColloids and surfaces B: biointerfacespt_BR
dc.relation.ispartofabbreviationColloid surf. B: biointerfacespt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2012-
dc.date.monthofcirculationMaypt_BR
dc.language.isoengpt_BR
dc.description.volume93pt_BR
dc.description.firstpage36pt_BR
dc.description.lastpage40pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0927-7765pt_BR
dc.identifier.eissn1873-4367pt_BR
dc.identifier.doi10.1016/j.colsurfb.2011.11.051pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0927776511007144pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2020-09-09T12:23:22Z-
dc.date.accessioned2020-09-09T12:23:22Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2020-09-09T12:23:22Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:58Z : No. of bitstreams: 1 000302431900006.pdf: 580257 bytes, checksum: e073009fa1c5a24eff94582fe81c13f8 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-09T12:23:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348906-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Química Orgânicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.subject.keywordAll-trans retinoic acidpt_BR
dc.subject.keywordAntibacterial activitypt_BR
dc.subject.keywordCytotoxicitypt_BR
dc.subject.keywordSolid lipid nanoparticlespt_BR
dc.subject.keywordTretinoinpt_BR
dc.identifier.source000302431900006pt_BR
dc.creator.orcid0000-0001-6258-3959pt_BR
dc.creator.orcid0000-0003-0378-9580pt_BR
dc.creator.orcid0000-0002-2875-0781pt_BR
dc.creator.orcid0000-0002-9118-2596pt_BR
dc.creator.orcid0000-0002-6435-6159pt_BR
dc.creator.orcid0000-0001-8372-5143pt_BR
dc.type.formArtigopt_BR
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