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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampUeta, Marlene Tiduko-
dc.typeArtigopt_BR
dc.titleCounterregulation of Th2 immunity by interleukin 12 reduces host defenses against Strongyloides venezuelensis infectionpt_BR
dc.contributor.authorMachado, Eleuza R.-
dc.contributor.authorCarlos, Daniela-
dc.contributor.authorLourenco, Elaine V.-
dc.contributor.authorSorgi, Carlos A.-
dc.contributor.authorSilva, Erika V.-
dc.contributor.authorRamos, Simone G.-
dc.contributor.authorUeta, Marlene T.-
dc.contributor.authorAronoff, David M.-
dc.contributor.authorFaccioli, Lucia H.-
dc.subjectCitocinaspt_BR
dc.subject.otherlanguageCytokinespt_BR
dc.description.abstractThe aim of this study was to investigate the role of interleukin 12 (IL-12) during Strongyloides venezuelensis infection. IL-12(-/-) and wildtype C57BL/6 mice were subcutaneously infected with 1500 larvae of S. venezuelensis. On days 7, 14, and 21 post-infection, we determined eosinophil and mononuclear cell numbers in the blood and broncoalveolar lavage fluid (BALF), Th2 cytokine secretion in the lung parenchyma, and serum antibody levels. The numbers of eggs in the feces and worm parasites in the duodena were also quantified. The eosinophil and mononuclear cell counts and the concentrations of IL-3, IL-5, IL-10, IL-13, and IgG1 and IgE antibodies increased significantly in infected IL-12(-/-) and wild-type mice as compared with uninfected controls. However, the number of eosinophils and mononuclear cells in the blood and BALF and the Th2 cytokine levels in the lungs of infected IL-12-/- mice were greater than in infected wild-type C57BL/6 mice. In addition, serum IgE and IgG1 levels were also significantly enhanced in the infected mice lacking IL-12. Meanwhile, parasite burden and fecal egg counts were significantly decreased in infected IL-12-/- mice. Together, our results showed that the absence of IL-12 upregulates the Th2 immune response, which is important for control of S. venezuelensis infectionpt_BR
dc.relation.ispartofMicrobes and Infection: a journal on infectious agents and host defensespt_BR
dc.relation.ispartofabbreviationMicrobes. Infect.pt_BR
dc.publisher.cityIssy les Moulineaux Cedexpt_BR
dc.publisher.countryFrançapt_BR
dc.publisherElsevierpt_BR
dc.date.issued2009-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume11pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage571pt_BR
dc.description.lastpage578pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1286-4579pt_BR
dc.identifier.eissn1769-714Xpt_BR
dc.identifier.doi10.1016/j.micinf.2009.03.005pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1286457909000598pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber02/12856-2pt_BR
dc.date.available2020-09-09T12:18:16Z-
dc.date.accessioned2020-09-09T12:18:16Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-09-09T12:18:16Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:58Z : No. of bitstreams: 1 000267839100005.pdf: 860498 bytes, checksum: 77b7ffd9a9a4bb2b2292015c971872ba (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-09T12:18:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348903-
dc.contributor.departmentDepartamento de Biologia Animalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordS. venezuelensispt_BR
dc.subject.keywordEosinophilspt_BR
dc.subject.keywordAntibodiespt_BR
dc.subject.keywordIL-12(-/-) micept_BR
dc.identifier.source000267839100005pt_BR
dc.creator.orcid0000-0002-6604-4351pt_BR
dc.type.formArtigo originalpt_BR
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